| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06946.1 | EAQ07715.1 | SKA53_15401 | SKA53_12798 | Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Mannose-6-phosphate isomerase /; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.773 |
| EAQ06946.1 | EAQ07752.1 | SKA53_15401 | SKA53_12983 | Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | 0.763 |
| EAQ06946.1 | EAQ07753.1 | SKA53_15401 | SKA53_12988 | Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COG3118 Thioredoxin domain-containing protein. | 0.672 |
| EAQ07715.1 | EAQ06946.1 | SKA53_12798 | SKA53_15401 | Mannose-6-phosphate isomerase /; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.773 |
| EAQ07715.1 | EAQ07752.1 | SKA53_12798 | SKA53_12983 | Mannose-6-phosphate isomerase /; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | 0.421 |
| EAQ07715.1 | nadE | SKA53_12798 | SKA53_08994 | Mannose-6-phosphate isomerase /; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.483 |
| EAQ07715.1 | ribB | SKA53_12798 | SKA53_01971 | Mannose-6-phosphate isomerase /; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.459 |
| EAQ07735.1 | EAQ07752.1 | SKA53_12898 | SKA53_12983 | HAD-superfamily subfamily IIA hydrolase; COG0647 Predicted sugar phosphatases of the HAD superfamily. | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | 0.485 |
| EAQ07752.1 | EAQ06946.1 | SKA53_12983 | SKA53_15401 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.763 |
| EAQ07752.1 | EAQ07715.1 | SKA53_12983 | SKA53_12798 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | Mannose-6-phosphate isomerase /; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.421 |
| EAQ07752.1 | EAQ07735.1 | SKA53_12983 | SKA53_12898 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | HAD-superfamily subfamily IIA hydrolase; COG0647 Predicted sugar phosphatases of the HAD superfamily. | 0.485 |
| EAQ07752.1 | EAQ07753.1 | SKA53_12983 | SKA53_12988 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | COG3118 Thioredoxin domain-containing protein. | 0.543 |
| EAQ07752.1 | EAQ07754.1 | SKA53_12983 | SKA53_12993 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | Putative ATP-dependent protease La, LON; COG2802 Uncharacterized protein, similar to the N-terminal domain of Lon protease. | 0.487 |
| EAQ07752.1 | EAQ07755.1 | SKA53_12983 | SKA53_12998 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | Hypothetical protein; Belongs to the UPF0434 family. | 0.487 |
| EAQ07752.1 | folE2 | SKA53_12983 | SKA53_02116 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.432 |
| EAQ07752.1 | nadE | SKA53_12983 | SKA53_08994 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.836 |
| EAQ07752.1 | polA | SKA53_12983 | SKA53_15116 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.431 |
| EAQ07752.1 | ribB | SKA53_12983 | SKA53_01971 | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.747 |
| EAQ07753.1 | EAQ06946.1 | SKA53_12988 | SKA53_15401 | COG3118 Thioredoxin domain-containing protein. | Probable 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.672 |
| EAQ07753.1 | EAQ07752.1 | SKA53_12988 | SKA53_12983 | COG3118 Thioredoxin domain-containing protein. | Hydrolase, NUDIX family; COG1051 ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | 0.543 |