| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ05845.1 | EAQ05846.1 | SKA53_07062 | SKA53_07067 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 0.999 |
| EAQ05845.1 | EAQ06639.1 | SKA53_07062 | SKA53_13866 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.998 |
| EAQ05845.1 | EAQ07119.1 | SKA53_07062 | SKA53_01946 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.689 |
| EAQ05845.1 | EAQ07769.1 | SKA53_07062 | SKA53_13068 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.998 |
| EAQ05845.1 | ribB | SKA53_07062 | SKA53_01971 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.653 |
| EAQ05845.1 | trpE | SKA53_07062 | SKA53_03036 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.815 |
| EAQ05846.1 | EAQ05845.1 | SKA53_07067 | SKA53_07062 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| EAQ05846.1 | EAQ06639.1 | SKA53_07067 | SKA53_13866 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.818 |
| EAQ05846.1 | EAQ07119.1 | SKA53_07067 | SKA53_01946 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.684 |
| EAQ05846.1 | EAQ07769.1 | SKA53_07067 | SKA53_13068 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.994 |
| EAQ05846.1 | ribB | SKA53_07067 | SKA53_01971 | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.484 |
| EAQ06639.1 | EAQ05845.1 | SKA53_13866 | SKA53_07062 | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
| EAQ06639.1 | EAQ05846.1 | SKA53_13866 | SKA53_07067 | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 0.818 |
| EAQ06639.1 | EAQ07119.1 | SKA53_13866 | SKA53_01946 | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.596 |
| EAQ06639.1 | EAQ07769.1 | SKA53_13866 | SKA53_13068 | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. | 0.857 |
| EAQ06639.1 | ribB | SKA53_13866 | SKA53_01971 | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.544 |
| EAQ06639.1 | trpE | SKA53_13866 | SKA53_03036 | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.419 |
| EAQ07119.1 | EAQ05845.1 | SKA53_01946 | SKA53_07062 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.689 |
| EAQ07119.1 | EAQ05846.1 | SKA53_01946 | SKA53_07067 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydroneopterin aldolase, putative; COG1539 Dihydroneopterin aldolase. | 0.684 |
| EAQ07119.1 | EAQ06639.1 | SKA53_01946 | SKA53_13866 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | folC bifunctional protein; COG0285 Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.596 |