| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06494.1 | EAQ07525.1 | SKA53_05383 | SKA53_11848 | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.430 |
| EAQ06494.1 | dut | SKA53_05383 | SKA53_14786 | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
| EAQ06494.1 | ndk | SKA53_05383 | SKA53_05208 | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.869 |
| EAQ06494.1 | tdk | SKA53_05383 | SKA53_09609 | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | COG1435 Thymidine kinase. | 0.477 |
| EAQ06494.1 | thyX | SKA53_05383 | SKA53_07631 | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.631 |
| EAQ06494.1 | tmk | SKA53_05383 | SKA53_06572 | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.713 |
| EAQ06822.1 | EAQ06824.1 | SKA53_14781 | SKA53_14791 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Molybdopterin biosynthesis protein MoeB, putative; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | 0.871 |
| EAQ06822.1 | EAQ06825.1 | SKA53_14781 | SKA53_14796 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Peptidyl-dipeptidase, putative; COG0339 Zn-dependent oligopeptidases. | 0.853 |
| EAQ06822.1 | EAQ08157.1 | SKA53_14781 | SKA53_10544 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.542 |
| EAQ06822.1 | dut | SKA53_14781 | SKA53_14786 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.991 |
| EAQ06822.1 | tmk | SKA53_14781 | SKA53_06572 | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.492 |
| EAQ06824.1 | EAQ06822.1 | SKA53_14791 | SKA53_14781 | Molybdopterin biosynthesis protein MoeB, putative; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.871 |
| EAQ06824.1 | EAQ06825.1 | SKA53_14791 | SKA53_14796 | Molybdopterin biosynthesis protein MoeB, putative; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Peptidyl-dipeptidase, putative; COG0339 Zn-dependent oligopeptidases. | 0.862 |
| EAQ06824.1 | EAQ08157.1 | SKA53_14791 | SKA53_10544 | Molybdopterin biosynthesis protein MoeB, putative; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.437 |
| EAQ06824.1 | dut | SKA53_14791 | SKA53_14786 | Molybdopterin biosynthesis protein MoeB, putative; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.862 |
| EAQ06825.1 | EAQ06822.1 | SKA53_14796 | SKA53_14781 | Peptidyl-dipeptidase, putative; COG0339 Zn-dependent oligopeptidases. | Phosphopantothenoylcysteine synthase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.853 |
| EAQ06825.1 | EAQ06824.1 | SKA53_14796 | SKA53_14791 | Peptidyl-dipeptidase, putative; COG0339 Zn-dependent oligopeptidases. | Molybdopterin biosynthesis protein MoeB, putative; COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2. | 0.862 |
| EAQ06825.1 | dut | SKA53_14796 | SKA53_14786 | Peptidyl-dipeptidase, putative; COG0339 Zn-dependent oligopeptidases. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.853 |
| EAQ07525.1 | EAQ06494.1 | SKA53_11848 | SKA53_05383 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 2''-deoxycytidine 5''-triphosphate deaminase-like protein; COG0717 Deoxycytidine deaminase. | 0.430 |
| EAQ07525.1 | dut | SKA53_11848 | SKA53_14786 | Putative deoxyribonucleotide triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.895 |
