| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ06090.1 | EAQ06396.1 | SKA53_08291 | SKA53_04893 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | 0.820 |
| EAQ06090.1 | EAQ06479.1 | SKA53_08291 | SKA53_05308 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | mazG family protein; COG1694 Predicted pyrophosphatase. | 0.831 |
| EAQ06090.1 | EAQ07905.1 | SKA53_08291 | SKA53_09284 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.822 |
| EAQ06090.1 | nadD | SKA53_08291 | SKA53_14836 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.823 |
| EAQ06090.1 | nadE | SKA53_08291 | SKA53_08994 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.828 |
| EAQ06090.1 | nadK | SKA53_08291 | SKA53_09409 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.815 |
| EAQ06090.1 | pncB | SKA53_08291 | SKA53_10494 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.834 |
| EAQ06090.1 | pntA | SKA53_08291 | SKA53_06287 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.815 |
| EAQ06090.1 | rsfS | SKA53_08291 | SKA53_14026 | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.446 |
| EAQ06396.1 | EAQ06090.1 | SKA53_04893 | SKA53_08291 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | 0.820 |
| EAQ06396.1 | EAQ06479.1 | SKA53_04893 | SKA53_05308 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | mazG family protein; COG1694 Predicted pyrophosphatase. | 0.815 |
| EAQ06396.1 | EAQ07905.1 | SKA53_04893 | SKA53_09284 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.824 |
| EAQ06396.1 | nadD | SKA53_04893 | SKA53_14836 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.907 |
| EAQ06396.1 | nadE | SKA53_04893 | SKA53_08994 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.909 |
| EAQ06396.1 | nadK | SKA53_04893 | SKA53_09409 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.478 |
| EAQ06396.1 | pncB | SKA53_04893 | SKA53_10494 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.899 |
| EAQ06396.1 | pntA | SKA53_04893 | SKA53_06287 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family. | 0.407 |
| EAQ06396.1 | rsfS | SKA53_04893 | SKA53_14026 | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.576 |
| EAQ06479.1 | EAQ06090.1 | SKA53_05308 | SKA53_08291 | mazG family protein; COG1694 Predicted pyrophosphatase. | Hydrolase, NUDIX family; COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding; Belongs to the Nudix hydrolase family. | 0.831 |
| EAQ06479.1 | EAQ06396.1 | SKA53_05308 | SKA53_04893 | mazG family protein; COG1694 Predicted pyrophosphatase. | Competence/damage-inducible protein CinA domain protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | 0.815 |