| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR50545.1 | EAR50864.1 | OG2516_04376 | OG2516_00135 | AhpC/TSA family protein; COG1225 Peroxiredoxin. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.652 |
| EAR50848.1 | EAR50863.1 | OG2516_00055 | OG2516_00130 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | Hypothetical protein. | 0.628 |
| EAR50848.1 | EAR50864.1 | OG2516_00055 | OG2516_00135 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.594 |
| EAR50848.1 | EAR51560.1 | OG2516_00055 | OG2516_01536 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | Two-component sensor histidine kinase; COG2203 FOG: GAF domain. | 0.999 |
| EAR50848.1 | EAR52235.1 | OG2516_00055 | OG2516_02324 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | COG0174 Glutamine synthetase. | 0.570 |
| EAR50848.1 | EAR52236.1 | OG2516_00055 | OG2516_02329 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.483 |
| EAR50848.1 | EAR52866.1 | OG2516_00055 | OG2516_10401 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.703 |
| EAR50848.1 | nadE | OG2516_00055 | OG2516_08938 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.731 |
| EAR50863.1 | EAR50848.1 | OG2516_00130 | OG2516_00055 | Hypothetical protein. | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | 0.628 |
| EAR50863.1 | EAR50864.1 | OG2516_00130 | OG2516_00135 | Hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.714 |
| EAR50863.1 | EAR50865.1 | OG2516_00130 | OG2516_00140 | Hypothetical protein. | Hypothetical protein. | 0.712 |
| EAR50864.1 | EAR50545.1 | OG2516_00135 | OG2516_04376 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | AhpC/TSA family protein; COG1225 Peroxiredoxin. | 0.652 |
| EAR50864.1 | EAR50848.1 | OG2516_00135 | OG2516_00055 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | 0.594 |
| EAR50864.1 | EAR50863.1 | OG2516_00135 | OG2516_00130 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein. | 0.714 |
| EAR50864.1 | EAR50865.1 | OG2516_00135 | OG2516_00140 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Hypothetical protein. | 0.860 |
| EAR50864.1 | EAR51560.1 | OG2516_00135 | OG2516_01536 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Two-component sensor histidine kinase; COG2203 FOG: GAF domain. | 0.531 |
| EAR50864.1 | EAR52235.1 | OG2516_00135 | OG2516_02324 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | COG0174 Glutamine synthetase. | 0.576 |
| EAR50864.1 | EAR52236.1 | OG2516_00135 | OG2516_02329 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | COG0347 Nitrogen regulatory protein PII; Belongs to the P(II) protein family. | 0.491 |
| EAR50864.1 | EAR52866.1 | OG2516_00135 | OG2516_10401 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.671 |
| EAR50864.1 | glnD | OG2516_00135 | OG2516_16966 | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.834 |
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