| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR49817.1 | EAR50277.1 | OG2516_08683 | OG2516_14663 | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.884 |
| EAR49817.1 | EAR51368.1 | OG2516_08683 | OG2516_15429 | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | 0.422 |
| EAR49817.1 | EAR51371.1 | OG2516_08683 | OG2516_15444 | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | COG1820 N-acetylglucosamine-6-phosphate deacetylase. | 0.527 |
| EAR49817.1 | glmM | OG2516_08683 | OG2516_07390 | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.770 |
| EAR50008.1 | EAR50009.1 | OG2516_07395 | OG2516_07400 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | COG1539 Dihydroneopterin aldolase. | 0.998 |
| EAR50008.1 | glmM | OG2516_07395 | OG2516_07390 | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.916 |
| EAR50009.1 | EAR50008.1 | OG2516_07400 | OG2516_07395 | COG1539 Dihydroneopterin aldolase. | Dihydropteroate synthase, DHPS; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.998 |
| EAR50009.1 | glmM | OG2516_07400 | OG2516_07390 | COG1539 Dihydroneopterin aldolase. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.811 |
| EAR50277.1 | EAR49817.1 | OG2516_14663 | OG2516_08683 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | 0.884 |
| EAR50277.1 | EAR51929.1 | OG2516_14663 | OG2516_12929 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains. | 0.808 |
| EAR50277.1 | glmM | OG2516_14663 | OG2516_07390 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.918 |
| EAR50277.1 | glmS | OG2516_14663 | OG2516_01209 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.808 |
| EAR50277.1 | glmU | OG2516_14663 | OG2516_01214 | Mannose-6-phosphate isomerase; COG0836 Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.504 |
| EAR51368.1 | EAR49817.1 | OG2516_15429 | OG2516_08683 | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | 0.422 |
| EAR51368.1 | EAR51371.1 | OG2516_15429 | OG2516_15444 | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | COG1820 N-acetylglucosamine-6-phosphate deacetylase. | 0.991 |
| EAR51368.1 | EAR51929.1 | OG2516_15429 | OG2516_12929 | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains. | 0.933 |
| EAR51368.1 | glmM | OG2516_15429 | OG2516_07390 | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | Phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.828 |
| EAR51368.1 | glmS | OG2516_15429 | OG2516_01209 | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.859 |
| EAR51368.1 | glmU | OG2516_15429 | OG2516_01214 | Probable aminotransferase; COG2222 Predicted phosphosugar isomerases. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.459 |
| EAR51371.1 | EAR49817.1 | OG2516_15444 | OG2516_08683 | COG1820 N-acetylglucosamine-6-phosphate deacetylase. | PTS system IIA component, Man family protein; COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. | 0.527 |