| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR50476.1 | EAR52859.1 | OG2516_09063 | OG2516_10366 | Membrane protein, putative. | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | 0.696 |
| EAR50761.1 | EAR52859.1 | OG2516_10169 | OG2516_10366 | Putative gluconokinase; COG3265 Gluconate kinase. | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | 0.885 |
| EAR51065.1 | EAR52859.1 | OG2516_04184 | OG2516_10366 | TdcF protein; COG2010 Cytochrome c, mono- and diheme variants. | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | 0.606 |
| EAR51065.1 | nnrD | OG2516_04184 | OG2516_02334 | TdcF protein; COG2010 Cytochrome c, mono- and diheme variants. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.419 |
| EAR51627.1 | EAR52859.1 | OG2516_01871 | OG2516_10366 | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | 0.628 |
| EAR52707.1 | EAR52859.1 | OG2516_00734 | OG2516_10366 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | 0.853 |
| EAR52707.1 | cobB-2 | OG2516_00734 | OG2516_08948 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily. | 0.868 |
| EAR52707.1 | pncB | OG2516_00734 | OG2516_10796 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.883 |
| EAR52859.1 | EAR50476.1 | OG2516_10366 | OG2516_09063 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | Membrane protein, putative. | 0.696 |
| EAR52859.1 | EAR50761.1 | OG2516_10366 | OG2516_10169 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | Putative gluconokinase; COG3265 Gluconate kinase. | 0.885 |
| EAR52859.1 | EAR51065.1 | OG2516_10366 | OG2516_04184 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | TdcF protein; COG2010 Cytochrome c, mono- and diheme variants. | 0.606 |
| EAR52859.1 | EAR51627.1 | OG2516_10366 | OG2516_01871 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | RNA methyltransferase, TrmH family, group 1; COG0565 rRNA methylase. | 0.628 |
| EAR52859.1 | EAR52707.1 | OG2516_10366 | OG2516_00734 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.853 |
| EAR52859.1 | EAR52860.1 | OG2516_10366 | OG2516_10371 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | Putative transporter, RarD family, DMT superfamily protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | 0.752 |
| EAR52859.1 | EAR52861.1 | OG2516_10366 | OG2516_10376 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | Hypothetical protein. | 0.557 |
| EAR52859.1 | cobB-2 | OG2516_10366 | OG2516_08948 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily. | 0.866 |
| EAR52859.1 | nnrD | OG2516_10366 | OG2516_02334 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.644 |
| EAR52859.1 | pncB | OG2516_10366 | OG2516_10796 | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.992 |
| EAR52860.1 | EAR52859.1 | OG2516_10371 | OG2516_10366 | Putative transporter, RarD family, DMT superfamily protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | Pyrazinamidase/nicotinamidase; COG1335 Amidases related to nicotinamidase. | 0.752 |
| EAR52860.1 | EAR52861.1 | OG2516_10371 | OG2516_10376 | Putative transporter, RarD family, DMT superfamily protein; COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily. | Hypothetical protein. | 0.572 |