| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR49688.1 | EAR52992.1 | OG2516_03498 | OG2516_11031 | mazG family protein; COG1694 Predicted pyrophosphatase. | COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.854 |
| EAR49688.1 | nadD | OG2516_03498 | OG2516_13916 | mazG family protein; COG1694 Predicted pyrophosphatase. | Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.845 |
| EAR49688.1 | pncB | OG2516_03498 | OG2516_10796 | mazG family protein; COG1694 Predicted pyrophosphatase. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.870 |
| EAR49688.1 | surE | OG2516_03498 | OG2516_04738 | mazG family protein; COG1694 Predicted pyrophosphatase. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.852 |
| EAR49766.1 | EAR52417.1 | OG2516_04693 | OG2516_08067 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.403 |
| EAR49766.1 | EAR52991.1 | OG2516_04693 | OG2516_11026 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG0029 Aspartate oxidase. | 0.403 |
| EAR49766.1 | EAR52992.1 | OG2516_04693 | OG2516_11031 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.638 |
| EAR49766.1 | nadA | OG2516_04693 | OG2516_11021 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.669 |
| EAR49766.1 | nadD | OG2516_04693 | OG2516_13916 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.815 |
| EAR49766.1 | nadE | OG2516_04693 | OG2516_08938 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.702 |
| EAR49766.1 | pncB | OG2516_04693 | OG2516_10796 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.536 |
| EAR50567.1 | EAR52992.1 | OG2516_04486 | OG2516_11031 | Putative competence-damaged inducible protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.870 |
| EAR50567.1 | nadD | OG2516_04486 | OG2516_13916 | Putative competence-damaged inducible protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Nicotinic acid mononucleotide adenyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.934 |
| EAR50567.1 | nadE | OG2516_04486 | OG2516_08938 | Putative competence-damaged inducible protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.888 |
| EAR50567.1 | pncB | OG2516_04486 | OG2516_10796 | Putative competence-damaged inducible protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.888 |
| EAR50567.1 | surE | OG2516_04486 | OG2516_04738 | Putative competence-damaged inducible protein; COG1546 Uncharacterized protein (competence- and mitomycin-induced); Belongs to the CinA family. | Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.857 |
| EAR52417.1 | EAR49766.1 | OG2516_08067 | OG2516_04693 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.403 |
| EAR52417.1 | EAR52992.1 | OG2516_08067 | OG2516_11031 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | COG0157 Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. | 0.870 |
| EAR52417.1 | nadA | OG2516_08067 | OG2516_11021 | COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. | 0.494 |
| EAR52991.1 | EAR49766.1 | OG2516_11026 | OG2516_04693 | COG0029 Aspartate oxidase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.403 |