| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR49712.1 | EAR50001.1 | OG2516_12431 | OG2516_07360 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.879 |
| EAR49712.1 | EAR50749.1 | OG2516_12431 | OG2516_10109 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | 0.544 |
| EAR49712.1 | ubiA | OG2516_12431 | OG2516_16651 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.679 |
| EAR49712.1 | ubiE | OG2516_12431 | OG2516_10114 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.938 |
| EAR49712.1 | ubiG | OG2516_12431 | OG2516_11481 | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.974 |
| EAR50001.1 | EAR49712.1 | OG2516_07360 | OG2516_12431 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.879 |
| EAR50001.1 | EAR50749.1 | OG2516_07360 | OG2516_10109 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | 0.647 |
| EAR50001.1 | ubiA | OG2516_07360 | OG2516_16651 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.579 |
| EAR50001.1 | ubiE | OG2516_07360 | OG2516_10114 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.948 |
| EAR50001.1 | ubiG | OG2516_07360 | OG2516_11481 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.979 |
| EAR50638.1 | ubiG | OG2516_12341 | OG2516_11481 | Molybdenum cofactor biosynthesis domain protein; COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.681 |
| EAR50749.1 | EAR49712.1 | OG2516_10109 | OG2516_12431 | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.544 |
| EAR50749.1 | EAR50001.1 | OG2516_10109 | OG2516_07360 | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.647 |
| EAR50749.1 | ubiA | OG2516_10109 | OG2516_16651 | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | 4-hydroxybenzoate polyprenyl transferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.434 |
| EAR50749.1 | ubiE | OG2516_10109 | OG2516_10114 | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.880 |
| EAR50749.1 | ubiG | OG2516_10109 | OG2516_11481 | 2-polyprenylphenol 6-hydroxylase; COG0661 Predicted unusual protein kinase. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.841 |
| EAR51378.1 | ubiG | OG2516_15479 | OG2516_11481 | 3-demethylubiquinone-9 3-methyltransferase; COG3865 Uncharacterized protein conserved in bacteria. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.826 |
| EAR51519.1 | gcvP | OG2516_01331 | OG2516_14945 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.775 |
| EAR51519.1 | ubiG | OG2516_01331 | OG2516_11481 | COG0372 Citrate synthase; Belongs to the citrate synthase family. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.708 |
| EAR53083.1 | ubiG | OG2516_11486 | OG2516_11481 | Proline iminopeptidase; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Belongs to the peptidase S33 family. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.719 |