| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR52398.1 | EAR53020.1 | OG2516_07972 | OG2516_11171 | Hypothetical protein; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. | Hypothetical protein; COG0802 Predicted ATPase or kinase. | 0.994 |
| EAR52398.1 | tsaD | OG2516_07972 | OG2516_11656 | Hypothetical protein; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. | Glycoprotease (M22) metalloprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.995 |
| EAR53020.1 | EAR52398.1 | OG2516_11171 | OG2516_07972 | Hypothetical protein; COG0802 Predicted ATPase or kinase. | Hypothetical protein; COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone. | 0.994 |
| EAR53020.1 | tsaD | OG2516_11171 | OG2516_11656 | Hypothetical protein; COG0802 Predicted ATPase or kinase. | Glycoprotease (M22) metalloprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.978 |
| EAR53114.1 | EAR53115.1 | OG2516_11641 | OG2516_11646 | Hypothetical protein. | Hypothetical protein. | 0.716 |
| EAR53114.1 | EAR53118.1 | OG2516_11641 | OG2516_11661 | Hypothetical protein. | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.529 |
| EAR53114.1 | gpsA | OG2516_11641 | OG2516_11651 | Hypothetical protein. | COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.682 |
| EAR53114.1 | tsaD | OG2516_11641 | OG2516_11656 | Hypothetical protein. | Glycoprotease (M22) metalloprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.700 |
| EAR53115.1 | EAR53114.1 | OG2516_11646 | OG2516_11641 | Hypothetical protein. | Hypothetical protein. | 0.716 |
| EAR53115.1 | EAR53118.1 | OG2516_11646 | OG2516_11661 | Hypothetical protein. | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.719 |
| EAR53115.1 | gpsA | OG2516_11646 | OG2516_11651 | Hypothetical protein. | COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.855 |
| EAR53115.1 | tsaD | OG2516_11646 | OG2516_11656 | Hypothetical protein. | Glycoprotease (M22) metalloprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.870 |
| EAR53118.1 | EAR53114.1 | OG2516_11661 | OG2516_11641 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein. | 0.529 |
| EAR53118.1 | EAR53115.1 | OG2516_11661 | OG2516_11646 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein. | 0.719 |
| EAR53118.1 | gpsA | OG2516_11661 | OG2516_11651 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | COG0240 Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.719 |
| EAR53118.1 | tsaD | OG2516_11661 | OG2516_11656 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glycoprotease (M22) metalloprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.795 |
| fusA | ksgA | OG2516_08506 | OG2516_04883 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.566 |
| fusA | lepA | OG2516_08506 | OG2516_13389 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.546 |
| fusA | pheS | OG2516_08506 | OG2516_10351 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | COG0016 Phenylalanyl-tRNA synthetase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. | 0.893 |
| fusA | tsaD | OG2516_08506 | OG2516_11656 | Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | Glycoprotease (M22) metalloprotease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.707 |
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