| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR49766.1 | EAR52665.1 | OG2516_04693 | OG2516_00524 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 2-dehydropantoate 2-reductase; COG1893 Ketopantoate reductase. | 0.424 |
| EAR49766.1 | guaA | OG2516_04693 | OG2516_02504 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.595 |
| EAR49766.1 | panB | OG2516_04693 | OG2516_13771 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.624 |
| EAR49766.1 | panC | OG2516_04693 | OG2516_13776 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.606 |
| EAR50777.1 | EAR51427.1 | OG2516_09268 | OG2516_16941 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.824 |
| EAR50777.1 | EAR52442.1 | OG2516_09268 | OG2516_08192 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.934 |
| EAR50777.1 | EAR53061.1 | OG2516_09268 | OG2516_11376 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.876 |
| EAR50777.1 | ilvD | OG2516_09268 | OG2516_12311 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.934 |
| EAR50777.1 | ilvE | OG2516_09268 | OG2516_12211 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Branched chain acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.822 |
| EAR50777.1 | panB | OG2516_09268 | OG2516_13771 | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.813 |
| EAR51427.1 | EAR50777.1 | OG2516_16941 | OG2516_09268 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.824 |
| EAR51427.1 | EAR52442.1 | OG2516_16941 | OG2516_08192 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.919 |
| EAR51427.1 | EAR53061.1 | OG2516_16941 | OG2516_11376 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.822 |
| EAR51427.1 | ilvD | OG2516_16941 | OG2516_12311 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.958 |
| EAR51427.1 | panB | OG2516_16941 | OG2516_13771 | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.802 |
| EAR52442.1 | EAR50777.1 | OG2516_08192 | OG2516_09268 | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | Aminotransferase class IV, putative D-alanine aminotransferase; COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.934 |
| EAR52442.1 | EAR51427.1 | OG2516_08192 | OG2516_16941 | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.919 |
| EAR52442.1 | EAR53061.1 | OG2516_08192 | OG2516_11376 | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase. | 0.944 |
| EAR52442.1 | guaA | OG2516_08192 | OG2516_02504 | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.467 |
| EAR52442.1 | ilvE | OG2516_08192 | OG2516_12211 | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | Branched chain acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.919 |