| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAR49628.1 | EAR49630.1 | OG2516_15104 | OG2516_15114 | DNA processing protein DprA, putative; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | 0.663 |
| EAR49628.1 | EAR50848.1 | OG2516_15104 | OG2516_00055 | DNA processing protein DprA, putative; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | 0.721 |
| EAR49628.1 | topA | OG2516_15104 | OG2516_15099 | DNA processing protein DprA, putative; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.965 |
| EAR49630.1 | EAR49628.1 | OG2516_15114 | OG2516_15104 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | DNA processing protein DprA, putative; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | 0.663 |
| EAR49630.1 | EAR49631.1 | OG2516_15114 | OG2516_15119 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | Cytochrome c oxidase polypeptide II precursor (Cytochrome AA3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | 0.400 |
| EAR49630.1 | EAR50495.1 | OG2516_15114 | OG2516_09630 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.437 |
| EAR49630.1 | EAR50848.1 | OG2516_15114 | OG2516_00055 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | 0.426 |
| EAR49630.1 | EAR50936.1 | OG2516_15114 | OG2516_13726 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | Peptidyl-dipeptidase, putative; COG0339 Zn-dependent oligopeptidases. | 0.500 |
| EAR49630.1 | EAR52230.1 | OG2516_15114 | OG2516_02299 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | COG0015 Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.410 |
| EAR49630.1 | EAR53164.1 | OG2516_15114 | OG2516_11891 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | PmbA; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | 0.966 |
| EAR49630.1 | ctaB | OG2516_15114 | OG2516_15124 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.400 |
| EAR49630.1 | ksgA | OG2516_15114 | OG2516_04883 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.403 |
| EAR49630.1 | topA | OG2516_15114 | OG2516_15099 | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.431 |
| EAR49631.1 | EAR49630.1 | OG2516_15119 | OG2516_15114 | Cytochrome c oxidase polypeptide II precursor (Cytochrome AA3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | 0.400 |
| EAR49631.1 | EAR50848.1 | OG2516_15119 | OG2516_00055 | Cytochrome c oxidase polypeptide II precursor (Cytochrome AA3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | 0.489 |
| EAR49631.1 | ctaB | OG2516_15119 | OG2516_15124 | Cytochrome c oxidase polypeptide II precursor (Cytochrome AA3 subunit 2); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. | 0.999 |
| EAR50495.1 | EAR49630.1 | OG2516_09630 | OG2516_15114 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | 0.437 |
| EAR50495.1 | EAR50848.1 | OG2516_09630 | OG2516_00055 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | 0.400 |
| EAR50848.1 | EAR49628.1 | OG2516_00055 | OG2516_15104 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | DNA processing protein DprA, putative; COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | 0.721 |
| EAR50848.1 | EAR49630.1 | OG2516_00055 | OG2516_15114 | PAS; COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. | Probable modulator of DNA gyrase; COG0312 Predicted Zn-dependent proteases and their inactivated homologs. | 0.426 |