Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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EAQ25682.1L-threonine aldolase, low-specificity, putative; COG2008 Threonine aldolase. (348 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
  
 0.953
EAQ25163.1
COG0112 Glycine/serine hydroxymethyltransferase.
    
 0.916
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
 0.916
EAQ25306.1
COG0498 Threonine synthase.
    
 0.914
EAQ25680.1
Riboflavin biosynthesis protein RibF; COG0196 FAD synthase; Belongs to the ribF family.
     
 0.889
EAQ23135.1
COG4583 Sarcosine oxidase gamma subunit.
  
  
  0.867
EAQ23136.1
Sarcosine oxidase, alpha subunit family protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family.
   
 0.863
EAQ25422.1
Pyridoxal-phosphate dependent enzyme family protein; COG1171 Threonine dehydratase.
   
 
 0.861
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 
 0.861
EAQ23948.1
COG1171 Threonine dehydratase.
   
 
 0.861
Your Current Organism:
Roseovarius sp. 217
NCBI taxonomy Id: 314264
Other names: R. sp. 217
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