Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ccmCABC heme exporter, inner membrane subunit CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (246 aa)    
Predicted Functional Partners:
EAQ27203.1
Heme exporter protein CcmB; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
 0.999
ccmE
Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 0.998
ccmA
Heme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
 0.997
EAQ27201.1
Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.
  
 0.977
EAQ27200.1
Probable thiol-disulfide interchange protein; COG0526 Thiol-disulfide isomerase and thioredoxins.
 
  
 0.969
EAQ27132.1
Cytochrome c-type biogenesis protein CcmF; COG1138 Cytochrome c biogenesis factor.
 
  
 0.903
EAQ23295.1
Cytochrome c-type biogenesis protein CcmH; Possible subunit of a heme lyase.
 
  
 0.831
EAQ27131.1
Cytochrome c maturation protein, CcmH; Possible subunit of a heme lyase.
 
  
 0.831
EAQ23297.1
Hypothetical protein; COG1138 Cytochrome c biogenesis factor.
 
     0.816
EAQ24622.1
ABC transporter, ATP-binding protein; COG1137 ABC-type (unclassified) transport system, ATPase component.
    
 0.793
Your Current Organism:
Roseovarius sp. 217
NCBI taxonomy Id: 314264
Other names: R. sp. 217
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