node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAT07659.1 | EAT09746.1 | SKA58_00110 | SKA58_15657 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis. | 0.680 |
EAT07659.1 | hisA | SKA58_00110 | SKA58_04451 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.843 |
EAT07659.1 | hisB | SKA58_00110 | SKA58_04441 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.970 |
EAT07659.1 | hisD | SKA58_00110 | SKA58_03154 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.957 |
EAT07659.1 | hisE | SKA58_00110 | SKA58_04466 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.786 |
EAT07659.1 | hisF | SKA58_00110 | SKA58_04456 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.948 |
EAT07659.1 | hisG | SKA58_00110 | SKA58_03149 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.850 |
EAT07659.1 | hisH | SKA58_00110 | SKA58_04446 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.957 |
EAT07659.1 | hisI | SKA58_00110 | SKA58_08020 | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.893 |
EAT09394.1 | hisA | SKA58_03740 | SKA58_04451 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.651 |
EAT09394.1 | hisB | SKA58_03740 | SKA58_04441 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.610 |
EAT09394.1 | hisD | SKA58_03740 | SKA58_03154 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.738 |
EAT09394.1 | hisE | SKA58_03740 | SKA58_04466 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.843 |
EAT09394.1 | hisF | SKA58_03740 | SKA58_04456 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.963 |
EAT09394.1 | hisG | SKA58_03740 | SKA58_03149 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.609 |
EAT09394.1 | hisH | SKA58_03740 | SKA58_04446 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.954 |
EAT09394.1 | hisI | SKA58_03740 | SKA58_08020 | Glutamate synthase [NADPH] large chain precursor; COG0067 Glutamate synthase domain 1. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.855 |
EAT09746.1 | EAT07659.1 | SKA58_15657 | SKA58_00110 | COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis. | Putative aminotransferase; COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. | 0.680 |
EAT09746.1 | hisA | SKA58_15657 | SKA58_04451 | COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis. | COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. | 0.943 |
EAT09746.1 | hisB | SKA58_15657 | SKA58_04441 | COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.956 |