node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDZ40918.1 | EDZ41676.1 | RB2083_432 | RB2083_1191 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.754 |
EDZ40918.1 | EDZ41762.1 | RB2083_432 | RB2083_1277 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | Phosphoenolpyruvate phosphomutase; [MI] COG0615 Cytidylyltransferase. | 0.739 |
EDZ40918.1 | EDZ43280.1 | RB2083_432 | RB2083_2795 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | 0.819 |
EDZ40918.1 | EDZ44034.1 | RB2083_432 | RB2083_3549 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | 2-isopropylmalate synthase/homocitrate synthase family protein; [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.750 |
EDZ40918.1 | ilvC | RB2083_432 | RB2083_2330 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.507 |
EDZ40918.1 | ilvD | RB2083_432 | RB2083_3405 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.515 |
EDZ40918.1 | ilvN | RB2083_432 | RB2083_239 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.814 |
EDZ40918.1 | leuA | RB2083_432 | RB2083_675 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.750 |
EDZ40918.1 | leuB | RB2083_432 | RB2083_2155 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.473 |
EDZ40918.1 | pdhB | RB2083_432 | RB2083_3058 | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | Pyruvate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.996 |
EDZ41676.1 | EDZ40918.1 | RB2083_1191 | RB2083_432 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | 0.754 |
EDZ41676.1 | EDZ41762.1 | RB2083_1191 | RB2083_1277 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | Phosphoenolpyruvate phosphomutase; [MI] COG0615 Cytidylyltransferase. | 0.763 |
EDZ41676.1 | EDZ43280.1 | RB2083_1191 | RB2083_2795 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | Phosphate acetyl/butyryl transferase subfamily, putative; [C] COG0281 Malic enzyme. | 0.754 |
EDZ41676.1 | EDZ44034.1 | RB2083_1191 | RB2083_3549 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase/homocitrate synthase family protein; [E] COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.730 |
EDZ41676.1 | ilvC | RB2083_1191 | RB2083_2330 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.934 |
EDZ41676.1 | ilvD | RB2083_1191 | RB2083_3405 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | [EG] COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.744 |
EDZ41676.1 | ilvN | RB2083_1191 | RB2083_239 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | [E] COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.989 |
EDZ41676.1 | leuA | RB2083_1191 | RB2083_675 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.764 |
EDZ41676.1 | leuB | RB2083_1191 | RB2083_2155 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.800 |
EDZ41676.1 | pdhB | RB2083_1191 | RB2083_3058 | Putative acetolactate synthase; [EH] COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | Pyruvate dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.717 |