EDZ41934.1 protein (Rhodobacteraceae bacterium HTCC2083)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EDZ41934.1

MaoC family protein; [I] COG2030 Acyl dehydratase. (326 aa)

Predicted Functional Partners:

citE

0.936

ccrA

0.922

mclA_2

0.905

ibd

0.889

EDZ44280.1

0.882

mclA_1

0.880

EDZ43274.1

0.860

EDZ43014.1

0.798

EDZ43598.1

0.759

EDZ40738.1

0.755

Your Current Organism:

Rhodobacteraceae bacterium HTCC2083

NCBI taxonomy Id: 314270
Other names: R. bacterium HTCC2083, Rhodobacterales bacterium HTCC2083

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EDZ40738.1	EDZ41934.1	RB2083_252	RB2083_1449	NnrU; [S] COG4094 Predicted membrane protein.	MaoC family protein; [I] COG2030 Acyl dehydratase.	0.755
EDZ40738.1	EDZ43014.1	RB2083_252	RB2083_2529	NnrU; [S] COG4094 Predicted membrane protein.	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.663
EDZ40738.1	citE	RB2083_252	RB2083_3974	NnrU; [S] COG4094 Predicted membrane protein.	[G] COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.	0.805
EDZ41934.1	EDZ40738.1	RB2083_1449	RB2083_252	MaoC family protein; [I] COG2030 Acyl dehydratase.	NnrU; [S] COG4094 Predicted membrane protein.	0.755
EDZ41934.1	EDZ43014.1	RB2083_1449	RB2083_2529	MaoC family protein; [I] COG2030 Acyl dehydratase.	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	0.798
EDZ41934.1	EDZ43274.1	RB2083_1449	RB2083_2789	MaoC family protein; [I] COG2030 Acyl dehydratase.	KR domain family; [Q] COG3321 Polyketide synthase modules and related proteins.	0.860
EDZ41934.1	EDZ43598.1	RB2083_1449	RB2083_3113	MaoC family protein; [I] COG2030 Acyl dehydratase.	Short-chain dehydrogenase/reductase SDR; [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).	0.759
EDZ41934.1	EDZ44280.1	RB2083_1449	RB2083_3795	MaoC family protein; [I] COG2030 Acyl dehydratase.	[I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit.	0.882
EDZ41934.1	ccrA	RB2083_1449	RB2083_3562	MaoC family protein; [I] COG2030 Acyl dehydratase.	[CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases.	0.922
EDZ41934.1	citE	RB2083_1449	RB2083_3974	MaoC family protein; [I] COG2030 Acyl dehydratase.	[G] COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.	0.936
EDZ41934.1	ibd	RB2083_1449	RB2083_1035	MaoC family protein; [I] COG2030 Acyl dehydratase.	[I] COG1960 Acyl-CoA dehydrogenases.	0.889
EDZ41934.1	mclA_1	RB2083_1449	RB2083_1259	MaoC family protein; [I] COG2030 Acyl dehydratase.	[G] COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.	0.880
EDZ41934.1	mclA_2	RB2083_1449	RB2083_2112	MaoC family protein; [I] COG2030 Acyl dehydratase.	[G] COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.	0.905
EDZ43014.1	EDZ40738.1	RB2083_2529	RB2083_252	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	NnrU; [S] COG4094 Predicted membrane protein.	0.663
EDZ43014.1	EDZ41934.1	RB2083_2529	RB2083_1449	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	MaoC family protein; [I] COG2030 Acyl dehydratase.	0.798
EDZ43014.1	citE	RB2083_2529	RB2083_3974	Conserved hypothetical protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit.	[G] COG2301 Citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family.	0.615
EDZ43274.1	EDZ41934.1	RB2083_2789	RB2083_1449	KR domain family; [Q] COG3321 Polyketide synthase modules and related proteins.	MaoC family protein; [I] COG2030 Acyl dehydratase.	0.860
EDZ43274.1	EDZ43598.1	RB2083_2789	RB2083_3113	KR domain family; [Q] COG3321 Polyketide synthase modules and related proteins.	Short-chain dehydrogenase/reductase SDR; [IQR] COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).	0.943
EDZ43274.1	EDZ44280.1	RB2083_2789	RB2083_3795	KR domain family; [Q] COG3321 Polyketide synthase modules and related proteins.	[I] COG1884 Methylmalonyl-CoA mutase, N-terminal domain/subunit.	0.698
EDZ43274.1	ccrA	RB2083_2789	RB2083_3562	KR domain family; [Q] COG3321 Polyketide synthase modules and related proteins.	[CR] COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases.	0.952

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.695

expected number of edges:

11

PPI enrichment p-value:

9.53e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

9 of 210

1.08

1.29

4.63e-07

GO:0006810

Transport

11 of 304

1.0

1.24

1.05e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

3 of 23

1.56

0.69

0.0399

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

9 of 333

0.88

0.87

1.21e-05

GO:0016021

Integral component of membrane

7 of 569

0.54

0.34

0.0364

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2973

ABC transporter type 1, transmembrane domain MetI-like, and Bacterial extracellular solute-binding protein

11 of 18

2.23

8.2

3.31e-21

CL:2974

ABC transporter type 1, transmembrane domain MetI-like, and ABC transporter, maltose/maltodextrin import, MalK-like

7 of 12

2.21

5.27

2.19e-12

CL:2997

ABC transporter type 1, transmembrane domain MetI-like, and Bacterial extracellular solute-binding protein

4 of 6

2.27

3.01

1.12e-06

CL:2975

ABC transporter type 1, transmembrane domain MetI-like, and TOBE domain

4 of 6

2.27

3.01

1.12e-06

CL:2986

ABC transporter type 1, transmembrane domain MetI-like, and ABC transporter, maltose/maltodextrin import, MalK-like

3 of 6

2.14

1.97

0.00014

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 106

1.46

3.01

1.47e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0055052

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

6 of 6

2.45

5.4

1.22e-11

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

9 of 29

1.94

5.0

2.68e-14

GOCC:0110165

Cellular anatomical entity

11 of 1512

0.31

0.27

0.0063

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

9 of 77

1.51

2.81

6.08e-11

KW-1003

Cell membrane

7 of 74

1.42

2.05

1.73e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

7 of 15

2.11

4.6

4.05e-11

PF13416

Bacterial extracellular solute-binding protein

2 of 3

2.27

0.9

0.0217

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

7 of 15

2.11

4.45

1.05e-10

IPR035906

MetI-like superfamily

7 of 16

2.09

4.39

1.05e-10

IPR015855

ABC transporter, maltose/maltodextrin import, MalK-like

2 of 2

2.45

0.9

0.0226

IPR008995

Molybdate/tungstate binding, C-terminal

2 of 3

2.27

0.84

0.0282

IPR006059

Bacterial extracellular solute-binding protein

2 of 3

2.27

0.84

0.0282

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