node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDZ42672.1 | mutY | RB2083_2187 | RB2083_1725 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.610 |
EDZ42839.1 | EDZ42909.1 | RB2083_2354 | RB2083_2424 | [S] COG5389 Uncharacterized protein conserved in bacteria. | Fatty acid desaturase family protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | 0.440 |
EDZ42839.1 | EDZ43227.1 | RB2083_2354 | RB2083_2742 | [S] COG5389 Uncharacterized protein conserved in bacteria. | Dsba oxidoreductase:tat pathway signal; [O] COG1651 Protein-disulfide isomerase. | 0.865 |
EDZ42839.1 | mutY | RB2083_2354 | RB2083_1725 | [S] COG5389 Uncharacterized protein conserved in bacteria. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.599 |
EDZ42909.1 | EDZ42839.1 | RB2083_2424 | RB2083_2354 | Fatty acid desaturase family protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | [S] COG5389 Uncharacterized protein conserved in bacteria. | 0.440 |
EDZ42909.1 | EDZ43227.1 | RB2083_2424 | RB2083_2742 | Fatty acid desaturase family protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | Dsba oxidoreductase:tat pathway signal; [O] COG1651 Protein-disulfide isomerase. | 0.435 |
EDZ42909.1 | mutY | RB2083_2424 | RB2083_1725 | Fatty acid desaturase family protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.801 |
EDZ43227.1 | EDZ42839.1 | RB2083_2742 | RB2083_2354 | Dsba oxidoreductase:tat pathway signal; [O] COG1651 Protein-disulfide isomerase. | [S] COG5389 Uncharacterized protein conserved in bacteria. | 0.865 |
EDZ43227.1 | EDZ42909.1 | RB2083_2742 | RB2083_2424 | Dsba oxidoreductase:tat pathway signal; [O] COG1651 Protein-disulfide isomerase. | Fatty acid desaturase family protein; [K] COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit. | 0.435 |
EDZ43227.1 | mutY | RB2083_2742 | RB2083_1725 | Dsba oxidoreductase:tat pathway signal; [O] COG1651 Protein-disulfide isomerase. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.597 |
dnaN | mutM | RB2083_2374 | RB2083_1061 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.539 |
dnaN | mutY | RB2083_2374 | RB2083_1725 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.819 |
dnaN | xth_1 | RB2083_2374 | RB2083_833 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | [L] COG0708 Exonuclease III. | 0.925 |
dnaN | xth_2 | RB2083_2374 | RB2083_1465 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | [L] COG0708 Exonuclease III. | 0.925 |
mutM | dnaN | RB2083_1061 | RB2083_2374 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.539 |
mutM | mutY | RB2083_1061 | RB2083_1725 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.596 |
mutM | nth | RB2083_1061 | RB2083_2705 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.909 |
mutM | xth_1 | RB2083_1061 | RB2083_833 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | [L] COG0708 Exonuclease III. | 0.522 |
mutM | xth_2 | RB2083_1061 | RB2083_1465 | formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | [L] COG0708 Exonuclease III. | 0.522 |
mutY | EDZ42672.1 | RB2083_1725 | RB2083_2187 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.610 |