node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDZ43597.1 | ligA_2 | RB2083_3112 | RB2083_1452 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.913 |
EDZ43597.1 | polA | RB2083_3112 | RB2083_3805 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | DNA polymerase I superfamily; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.829 |
EDZ43597.1 | recF | RB2083_3112 | RB2083_2763 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.575 |
EDZ43597.1 | recG | RB2083_3112 | RB2083_2188 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.662 |
EDZ43597.1 | recJ | RB2083_3112 | RB2083_1753 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | single-stranded-DNA-specific exonuclease RecJ; [L] COG0608 Single-stranded DNA-specific exonuclease. | 0.462 |
EDZ43597.1 | recQ | RB2083_3112 | RB2083_2019 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | [LKJ] COG0513 Superfamily II DNA and RNA helicases. | 0.971 |
EDZ43597.1 | topA | RB2083_3112 | RB2083_2333 | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.863 |
EDZ44527.1 | ctrA | RB2083_4042 | RB2083_469 | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.629 |
EDZ44527.1 | recF | RB2083_4042 | RB2083_2763 | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.493 |
EDZ44527.1 | recG | RB2083_4042 | RB2083_2188 | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.651 |
EDZ44527.1 | recJ | RB2083_4042 | RB2083_1753 | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | single-stranded-DNA-specific exonuclease RecJ; [L] COG0608 Single-stranded DNA-specific exonuclease. | 0.699 |
EDZ44527.1 | ruvA | RB2083_4042 | RB2083_1372 | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.522 |
EDZ44527.1 | topA | RB2083_4042 | RB2083_2333 | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.920 |
ctrA | EDZ44527.1 | RB2083_469 | RB2083_4042 | [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | DNA protecting protein DprA; [LU] COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake. | 0.629 |
ctrA | ligA_2 | RB2083_469 | RB2083_1452 | [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | 0.597 |
ctrA | recF | RB2083_469 | RB2083_2763 | [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.591 |
ctrA | recG | RB2083_469 | RB2083_2188 | [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. | 0.725 |
ligA_2 | EDZ43597.1 | RB2083_1452 | RB2083_3112 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | UvrD/REP helicase domain protein; [L] COG0210 Superfamily I DNA and RNA helicases. | 0.913 |
ligA_2 | ctrA | RB2083_1452 | RB2083_469 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | [TK] COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. | 0.597 |
ligA_2 | polA | RB2083_1452 | RB2083_3805 | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. | DNA polymerase I superfamily; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.733 |