node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDZ43276.1 | hisA | RB2083_2791 | RB2083_586 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | 0.954 |
EDZ43276.1 | hisB | RB2083_2791 | RB2083_573 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | [E] COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.956 |
EDZ43276.1 | hisD_1 | RB2083_2791 | RB2083_732 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.895 |
EDZ43276.1 | hisD_2 | RB2083_2791 | RB2083_455 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.895 |
EDZ43276.1 | hisD_3 | RB2083_2791 | RB2083_2849 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.895 |
EDZ43276.1 | hisF | RB2083_2791 | RB2083_3914 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.976 |
EDZ43276.1 | hisG | RB2083_2791 | RB2083_1116 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
EDZ43276.1 | hisH | RB2083_2791 | RB2083_2832 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.946 |
EDZ43276.1 | hisI_1 | RB2083_2791 | RB2083_1678 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.974 |
EDZ43276.1 | hisI_2 | RB2083_2791 | RB2083_3067 | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.993 |
hisA | EDZ43276.1 | RB2083_586 | RB2083_2791 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | ATP phosphoribosyltransferase regulatory subunit; [J] COG0124 Histidyl-tRNA synthetase. | 0.954 |
hisA | hisB | RB2083_586 | RB2083_573 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | [E] COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.995 |
hisA | hisD_1 | RB2083_586 | RB2083_732 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.972 |
hisA | hisD_2 | RB2083_586 | RB2083_455 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.982 |
hisA | hisD_3 | RB2083_586 | RB2083_2849 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.961 |
hisA | hisF | RB2083_586 | RB2083_3914 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | RB2083_586 | RB2083_1116 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.983 |
hisA | hisH | RB2083_586 | RB2083_2832 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI_1 | RB2083_586 | RB2083_1678 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisI_2 | RB2083_586 | RB2083_3067 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; [E] COG0107 Imidazoleglycerol-phosphate synthase. | [E] COG0140 Phosphoribosyl-ATP pyrophosphohydrolase. | 0.998 |