STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metF_1[E] COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (288 aa)    
Predicted Functional Partners:
EDZ43156.1
Methionine synthase I; [E] COG2040 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent).
 
 
 0.979
EDZ42944.1
Dihydropteroate synthase (dhps); [E] COG1410 Methionine synthase I, cobalamin-binding domain.
 
 
 0.978
EDZ41465.1
[E] COG0620 Methionine synthase II (cobalamin-independent).
  
 0.963
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
  
  
 0.940
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.910
metF_2
[E] COG0685 5,10-methylenetetrahydrofolate reductase.
     
 0.888
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
  
 0.866
metC
Cystathionine beta-lyase; [E] COG0436 Aspartate/tyrosine/aromatic aminotransferase.
  
 0.866
EDZ43536.1
[E] COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases.
  
 0.866
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.852
Your Current Organism:
Rhodobacteraceae bacterium HTCC2083
NCBI taxonomy Id: 314270
Other names: R. bacterium HTCC2083, Rhodobacterales bacterium HTCC2083
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