STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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Textmining
[Homology]
Score
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (459 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.998
cbiC
precorrin-8X methylmutase; [S] COG2138 Uncharacterized conserved protein.
 
 
 0.997
cysI
[C] COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.995
EDZ41419.1
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.995
sat
Sulfate adenylyltransferase; Catalyzes the synthesis of activated sulfate.
  
  
 0.994
cobA
uroporphyrin-III C-methyltransferase; [H] COG0007 Uroporphyrinogen-III methylase; Belongs to the precorrin methyltransferase family.
 
 
0.981
EDZ44021.1
precorrin-3B methylase; [H] COG2073 Cobalamin biosynthesis protein CbiG.
 
 
 0.980
hemB
[H] COG0113 Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.978
cobI
Precorrin-2 C20-methyltransferase; [H] COG1010 Precorrin-3B methylase; Belongs to the precorrin methyltransferase family.
 
 
 0.973
cobL
precorrin-6Y C5,15-methyltransferase protein; [H] COG2241 Precorrin-6B methylase 1.
  
 
 0.964
Your Current Organism:
Rhodobacteraceae bacterium HTCC2083
NCBI taxonomy Id: 314270
Other names: R. bacterium HTCC2083, Rhodobacterales bacterium HTCC2083
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