STRINGSTRING
nrdR protein (Maritimibacter alkaliphilus) - STRING interaction network
"nrdR" - Transcriptional repressor NrdR in Maritimibacter alkaliphilus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRTranscriptional repressor NrdR ; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (145 aa)    
Predicted Functional Partners:
RB2654_05547
Riboflavin biosynthesis protein RibD ; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate (367 aa)
   
 
  0.974
RB2654_05510
Bifunctional GTP cyclohydrolaseII/3,4-dihydroxy-2butanone-4-phosphate synthase (379 aa)
         
  0.776
RB2654_10393
DNA polymerase I (932 aa)
 
     
  0.710
lexA
LexA repressor ; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (230 aa)
 
   
  0.613
RB2654_15931
Nucleotide-binding protein RB2654_15931 ; Displays ATPase and GTPase activities (297 aa)
 
          0.589
RB2654_18443
Glutamine-dependent NAD(+) synthetase (555 aa)
 
     
  0.586
ribH
6,7-dimethyl-8-ribityllumazine synthase ; Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (169 aa)
   
   
  0.550
RB2654_19073
Ribonucleoside-diphosphate reductase, putative (758 aa)
         
  0.533
RB2654_05557
Uncharacterized protein (138 aa)
              0.529
RB2654_20078
Histidinol dehydrogenase ; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (434 aa)
   
   
  0.526
Your Current Organism:
Maritimibacter alkaliphilus
NCBI taxonomy Id: 314271
Other names: M. alkaliphilus, M. alkaliphilus HTCC2654, Maritimibacter, Maritimibacter Lee et al. 2007, Maritimibacter alkaliphilus, Maritimibacter alkaliphilus HTCC2654, Maritimibacter alkaliphilus Lee et al. 2007, Maritimibacter alkaliphilus str. HTCC2654, Maritimibacter alkaliphilus strain HTCC2654, Rhodobacterales bacterium HTCC2654
Server load: low (8%) [HD]