STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMJ82714.1DNA topoisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.846
parE
DNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
   
 
 0.846
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
    
 
 0.826
AMJ81123.1
ATP-dependent DNA helicase RecQ; Functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.798
AMJ83541.1
Recombinase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 
 0.798
AMJ82250.1
General stress protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.727
AMJ83529.1
Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.720
AMJ84518.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.717
AMJ83522.1
Molybdopterin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.660
AMJ84277.1
ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 
 0.599
Your Current Organism:
Alteromonas mediterranea
NCBI taxonomy Id: 314275
Other names: A. mediterranea, Alteromonas mediterranea Ivanova et al. 2015, CIP 110805, DSM 17117, LMG 28347, LMG:28347, strain DE
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