| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ30917.1 | EAQ31274.1 | OS145_11374 | OS145_03417 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.652 |
| EAQ30917.1 | EAQ32210.1 | OS145_11374 | OS145_08262 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0407 Uroporphyrinogen-III decarboxylase. | 0.839 |
| EAQ30917.1 | hemN | OS145_11374 | OS145_02665 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.652 |
| EAQ30917.1 | miaB | OS145_11374 | OS145_12545 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 2-methylthioadenine synthetase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.427 |
| EAQ30917.1 | rdgB | OS145_11374 | OS145_03412 | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | Xanthosine triphosphate pyrophosphatase related enzyme; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.475 |
| EAQ31268.1 | EAQ31274.1 | OS145_03387 | OS145_03417 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.456 |
| EAQ31268.1 | EAQ31425.1 | OS145_03387 | OS145_04870 | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | COG0820 Predicted Fe-S-cluster redox enzyme; Belongs to the radical SAM superfamily. RlmN family. | 0.497 |
| EAQ31272.1 | EAQ31274.1 | OS145_03407 | OS145_03417 | COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.610 |
| EAQ31272.1 | rdgB | OS145_03407 | OS145_03412 | COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | Xanthosine triphosphate pyrophosphatase related enzyme; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.610 |
| EAQ31274.1 | EAQ30917.1 | OS145_03417 | OS145_11374 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Glutamate synthase, large subunit; COG0067 Glutamate synthase domain 1. | 0.652 |
| EAQ31274.1 | EAQ31268.1 | OS145_03417 | OS145_03387 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.456 |
| EAQ31274.1 | EAQ31272.1 | OS145_03417 | OS145_03407 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.610 |
| EAQ31274.1 | EAQ31425.1 | OS145_03417 | OS145_04870 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG0820 Predicted Fe-S-cluster redox enzyme; Belongs to the radical SAM superfamily. RlmN family. | 0.720 |
| EAQ31274.1 | EAQ32210.1 | OS145_03417 | OS145_08262 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG0407 Uroporphyrinogen-III decarboxylase. | 0.635 |
| EAQ31274.1 | EAQ33341.1 | OS145_03417 | OS145_03195 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG0408 Coproporphyrinogen III oxidase. | 0.564 |
| EAQ31274.1 | hemJ | OS145_03417 | OS145_07941 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG1981 Predicted membrane protein. | 0.541 |
| EAQ31274.1 | hemN | OS145_03417 | OS145_02665 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.586 |
| EAQ31274.1 | miaB | OS145_03417 | OS145_12545 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 2-methylthioadenine synthetase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. | 0.605 |
| EAQ31274.1 | rdgB | OS145_03417 | OS145_03412 | Uncharacterized Fe-S oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Xanthosine triphosphate pyrophosphatase related enzyme; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.862 |
| EAQ31425.1 | EAQ31268.1 | OS145_04870 | OS145_03387 | COG0820 Predicted Fe-S-cluster redox enzyme; Belongs to the radical SAM superfamily. RlmN family. | Predicted enzyme with a TIM-barrel fold; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. | 0.497 |