| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ31095.1 | EAQ31399.1 | OS145_05390 | OS145_04740 | COG0794 Predicted sugar phosphate isomerase involved in capsule formation. | COG0516 IMP dehydrogenase/GMP reductase. | 0.955 |
| EAQ31095.1 | guaA | OS145_05390 | OS145_04735 | COG0794 Predicted sugar phosphate isomerase involved in capsule formation. | Bifunctional GMP synthase/glutamine amidotransferase protein; COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.904 |
| EAQ31399.1 | EAQ31095.1 | OS145_04740 | OS145_05390 | COG0516 IMP dehydrogenase/GMP reductase. | COG0794 Predicted sugar phosphate isomerase involved in capsule formation. | 0.955 |
| EAQ31399.1 | EAQ31453.1 | OS145_04740 | OS145_10085 | COG0516 IMP dehydrogenase/GMP reductase. | COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase. | 0.956 |
| EAQ31399.1 | EAQ32857.1 | OS145_04740 | OS145_01822 | COG0516 IMP dehydrogenase/GMP reductase. | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | 0.955 |
| EAQ31399.1 | gmk | OS145_04740 | OS145_08587 | COG0516 IMP dehydrogenase/GMP reductase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.952 |
| EAQ31399.1 | guaA | OS145_04740 | OS145_04735 | COG0516 IMP dehydrogenase/GMP reductase. | Bifunctional GMP synthase/glutamine amidotransferase protein; COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.999 |
| EAQ31399.1 | purA | OS145_04740 | OS145_01955 | COG0516 IMP dehydrogenase/GMP reductase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.990 |
| EAQ31399.1 | purH | OS145_04740 | OS145_08187 | COG0516 IMP dehydrogenase/GMP reductase. | COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.995 |
| EAQ31399.1 | pyrD | OS145_04740 | OS145_06222 | COG0516 IMP dehydrogenase/GMP reductase. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.971 |
| EAQ31399.1 | rdgB | OS145_04740 | OS145_03412 | COG0516 IMP dehydrogenase/GMP reductase. | Xanthosine triphosphate pyrophosphatase related enzyme; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.942 |
| EAQ31399.1 | surE | OS145_04740 | OS145_07272 | COG0516 IMP dehydrogenase/GMP reductase. | SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.944 |
| EAQ31453.1 | EAQ31399.1 | OS145_10085 | OS145_04740 | COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase. | COG0516 IMP dehydrogenase/GMP reductase. | 0.956 |
| EAQ31453.1 | gmk | OS145_10085 | OS145_08587 | COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.630 |
| EAQ31453.1 | guaA | OS145_10085 | OS145_04735 | COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase. | Bifunctional GMP synthase/glutamine amidotransferase protein; COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.740 |
| EAQ31453.1 | purA | OS145_10085 | OS145_01955 | COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.482 |
| EAQ31453.1 | pyrD | OS145_10085 | OS145_06222 | COG0108 3,4-dihydroxy-2-butanone 4-phosphate synthase. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.455 |
| EAQ32857.1 | EAQ31399.1 | OS145_01822 | OS145_04740 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | COG0516 IMP dehydrogenase/GMP reductase. | 0.955 |
| EAQ32857.1 | gmk | OS145_01822 | OS145_08587 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.905 |
| EAQ32857.1 | guaA | OS145_01822 | OS145_04735 | COG0737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases; Belongs to the 5'-nucleotidase family. | Bifunctional GMP synthase/glutamine amidotransferase protein; COG0518 GMP synthase - Glutamine amidotransferase domain. | 0.908 |