Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
EAQ31488.1COG1199 Rad3-related DNA helicases. (645 aa)    
Predicted Functional Partners:
EAQ33338.1
DNA polymerase I; COG0258 5'-3' exonuclease (including N-terminal domain of PolI).
   
 0.921
EAQ33361.1
DNA polymerase sliding clamp subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...]
    
 0.871
tsaB
COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone.
     
 0.836
EAQ33278.1
Putative DNA repair helicase; COG3886 Predicted HKD family nuclease.
   
 0.831
EAQ32558.1
Putative ATP-dependent helicase; COG3886 Predicted HKD family nuclease.
   
 0.831
EAQ31003.1
COG0202 DNA-directed RNA polymerase, alpha subunit/40 kD subunit.
    
  0.825
sbcD
Exonuclease SbcD, putative; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 0.816
EAQ31379.1
COG0085 DNA-directed RNA polymerase, beta subunit/140 kD subunit.
    
 0.814
topA
COG0550 Topoisomerase IA; Belongs to the type IA topoisomerase family.
   
 0.739
rpoZ
DNA-directed RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
    
  0.699
Your Current Organism:
Idiomarina baltica
NCBI taxonomy Id: 314276
Other names: I. baltica OS145, Idiomarina baltica OS145, Idiomarina baltica str. OS145, Idiomarina baltica strain OS145
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