node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ63082.1 | EAQ64987.1 | MED121_19786 | MED121_09715 | COG0460 Homoserine dehydrogenase. | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.903 |
EAQ63082.1 | EAQ67485.1 | MED121_19786 | MED121_16199 | COG0460 Homoserine dehydrogenase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.905 |
EAQ63082.1 | ilvD | MED121_19786 | MED121_19906 | COG0460 Homoserine dehydrogenase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.903 |
EAQ63082.1 | ilvE | MED121_19786 | MED121_07710 | COG0460 Homoserine dehydrogenase. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.959 |
EAQ63082.1 | leuA | MED121_19786 | MED121_01170 | COG0460 Homoserine dehydrogenase. | Probable 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.914 |
EAQ63082.1 | leuB | MED121_19786 | MED121_00290 | COG0460 Homoserine dehydrogenase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.988 |
EAQ63082.1 | leuC | MED121_19786 | MED121_00280 | COG0460 Homoserine dehydrogenase. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.977 |
EAQ63082.1 | leuD | MED121_19786 | MED121_00285 | COG0460 Homoserine dehydrogenase. | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.979 |
EAQ63720.1 | EAQ63722.1 | MED121_03447 | MED121_03457 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Beta-ketoacyl synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | 0.999 |
EAQ63720.1 | EAQ64987.1 | MED121_03447 | MED121_09715 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.440 |
EAQ63720.1 | ilvD | MED121_03447 | MED121_19906 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.440 |
EAQ63720.1 | ilvE | MED121_03447 | MED121_07710 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.966 |
EAQ63720.1 | leuA | MED121_03447 | MED121_01170 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Probable 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.931 |
EAQ63720.1 | leuB | MED121_03447 | MED121_00290 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.571 |
EAQ63720.1 | leuC | MED121_03447 | MED121_00280 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.414 |
EAQ63722.1 | EAQ63720.1 | MED121_03457 | MED121_03447 | Beta-ketoacyl synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | 0.999 |
EAQ63722.1 | ilvE | MED121_03457 | MED121_07710 | Beta-ketoacyl synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.907 |
EAQ63722.1 | leuA | MED121_03457 | MED121_01170 | Beta-ketoacyl synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | Probable 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.919 |
EAQ63722.1 | leuB | MED121_03457 | MED121_00290 | Beta-ketoacyl synthase; COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.529 |
EAQ64987.1 | EAQ63082.1 | MED121_09715 | MED121_19786 | Putative dihydroxy-acid dehydratase protein; COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | COG0460 Homoserine dehydrogenase. | 0.903 |