| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ63089.1 | EAQ63090.1 | MED121_19821 | MED121_19826 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.792 |
| EAQ63089.1 | EAQ63720.1 | MED121_19821 | MED121_03447 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | 0.842 |
| EAQ63089.1 | coq7 | MED121_19821 | MED121_22262 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Hypothetical protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. | 0.610 |
| EAQ63089.1 | ubiA | MED121_19821 | MED121_10789 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.669 |
| EAQ63089.1 | ubiB | MED121_19821 | MED121_09193 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Hypothetical protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 0.491 |
| EAQ63089.1 | ubiE | MED121_19821 | MED121_09188 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.908 |
| EAQ63089.1 | ubiG | MED121_19821 | MED121_13480 | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.964 |
| EAQ63090.1 | EAQ63089.1 | MED121_19826 | MED121_19821 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.792 |
| EAQ63090.1 | EAQ63720.1 | MED121_19826 | MED121_03447 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | 0.842 |
| EAQ63090.1 | coq7 | MED121_19826 | MED121_22262 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Hypothetical protein; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. | 0.665 |
| EAQ63090.1 | ubiA | MED121_19826 | MED121_10789 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.708 |
| EAQ63090.1 | ubiB | MED121_19826 | MED121_09193 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Hypothetical protein; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 0.459 |
| EAQ63090.1 | ubiE | MED121_19826 | MED121_09188 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.913 |
| EAQ63090.1 | ubiG | MED121_19826 | MED121_13480 | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.970 |
| EAQ63720.1 | EAQ63089.1 | MED121_03447 | MED121_19821 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Ubiquinone biosynthesis hydroxylase; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.842 |
| EAQ63720.1 | EAQ63090.1 | MED121_03447 | MED121_19826 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.842 |
| EAQ63720.1 | EAQ65530.1 | MED121_03447 | MED121_22702 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Hypothetical protein; COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases. | 0.842 |
| EAQ63720.1 | EAQ65822.1 | MED121_03447 | MED121_01385 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | Sarcosine oxidase, alpha subunit family protein; COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Belongs to the GcvT family. | 0.950 |
| EAQ63720.1 | EAQ67360.1 | MED121_03447 | MED121_15574 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | COG1239 Mg-chelatase subunit ChlI. | 0.780 |
| EAQ63720.1 | ubiA | MED121_03447 | MED121_10789 | Amino acid adenylation; COG1020 Non-ribosomal peptide synthetase modules and related proteins. | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.744 |