| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EAQ63224.1 | EAQ65192.1 | MED121_24114 | MED121_18165 | COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Geranyltranstransferase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.969 |
| EAQ63224.1 | uppS | MED121_24114 | MED121_16389 | COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.969 |
| EAQ64202.1 | EAQ67521.1 | MED121_01180 | MED121_16379 | Hypothetical protein; COG0671 Membrane-associated phospholipid phosphatase. | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 0.503 |
| EAQ64202.1 | uppP-2 | MED121_01180 | MED121_16494 | Hypothetical protein; COG0671 Membrane-associated phospholipid phosphatase. | Bacitracin resistance protein (putative undecaprenol kinase); Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. | 0.938 |
| EAQ64202.1 | uppS | MED121_01180 | MED121_16389 | Hypothetical protein; COG0671 Membrane-associated phospholipid phosphatase. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.935 |
| EAQ65192.1 | EAQ63224.1 | MED121_18165 | MED121_24114 | Geranyltranstransferase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.969 |
| EAQ65192.1 | dxr | MED121_18165 | MED121_16374 | Geranyltranstransferase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.522 |
| EAQ65192.1 | uppS | MED121_18165 | MED121_16389 | Geranyltranstransferase; COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.976 |
| EAQ67519.1 | EAQ67521.1 | MED121_16369 | MED121_16379 | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 0.945 |
| EAQ67519.1 | dxr | MED121_16369 | MED121_16374 | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.922 |
| EAQ67519.1 | frr | MED121_16369 | MED121_16394 | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.763 |
| EAQ67519.1 | proS | MED121_16369 | MED121_21155 | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] | 0.576 |
| EAQ67519.1 | pyrH | MED121_16369 | MED121_16399 | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.834 |
| EAQ67519.1 | uppS | MED121_16369 | MED121_16389 | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.964 |
| EAQ67521.1 | EAQ64202.1 | MED121_16379 | MED121_01180 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Hypothetical protein; COG0671 Membrane-associated phospholipid phosphatase. | 0.503 |
| EAQ67521.1 | EAQ67519.1 | MED121_16379 | MED121_16369 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Membrane-associated zinc metalloprotease, putative; COG0750 Predicted membrane-associated Zn-dependent proteases 1. | 0.945 |
| EAQ67521.1 | dxr | MED121_16379 | MED121_16374 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.955 |
| EAQ67521.1 | frr | MED121_16379 | MED121_16394 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.803 |
| EAQ67521.1 | proS | MED121_16379 | MED121_21155 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] | 0.459 |
| EAQ67521.1 | pyrH | MED121_16379 | MED121_16399 | Phosphatidate cytidylyltransferase; COG0575 CDP-diglyceride synthetase; Belongs to the CDS family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.921 |