EAR20341.1 protein (Nitrococcus mobilis) - STRING interaction network

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Predicted Interactions

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Score

EAR20341.1

COG3963 Phospholipid N-methyltransferase. (191 aa)

Predicted Functional Partners:

EAR23094.1

0.906

EAR23206.1

0.667

psd

0.607

EAR23533.1

0.483

EAR20786.1

0.463

Your Current Organism:

Nitrococcus mobilis

NCBI taxonomy Id: 314278
Other names: N. mobilis Nb-231, Nitrococcus mobilis Nb-231, Nitrococcus mobilis str. Nb-231, Nitrococcus mobilis strain Nb-231

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR20341.1	EAR20786.1	NB231_06700	NB231_10934	COG3963 Phospholipid N-methyltransferase.	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	0.463
EAR20341.1	EAR23094.1	NB231_06700	NB231_14778	COG3963 Phospholipid N-methyltransferase.	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	0.906
EAR20341.1	EAR23206.1	NB231_06700	NB231_15338	COG3963 Phospholipid N-methyltransferase.	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.667
EAR20341.1	EAR23533.1	NB231_06700	NB231_16973	COG3963 Phospholipid N-methyltransferase.	Probable mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.483
EAR20341.1	psd	NB231_06700	NB231_00900	COG3963 Phospholipid N-methyltransferase.	Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).	0.607
EAR20786.1	EAR20341.1	NB231_10934	NB231_06700	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	COG3963 Phospholipid N-methyltransferase.	0.463
EAR20786.1	EAR23094.1	NB231_10934	NB231_14778	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	0.782
EAR20786.1	EAR23206.1	NB231_10934	NB231_15338	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.458
EAR20786.1	EAR23533.1	NB231_10934	NB231_16973	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	Probable mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.504
EAR20786.1	psd	NB231_10934	NB231_00900	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).	0.463
EAR23094.1	EAR20341.1	NB231_14778	NB231_06700	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	COG3963 Phospholipid N-methyltransferase.	0.906
EAR23094.1	EAR20786.1	NB231_14778	NB231_10934	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	0.782
EAR23094.1	EAR23206.1	NB231_14778	NB231_15338	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.934
EAR23094.1	EAR23533.1	NB231_14778	NB231_16973	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	Probable mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.869
EAR23094.1	psd	NB231_14778	NB231_00900	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).	0.936
EAR23206.1	EAR20341.1	NB231_15338	NB231_06700	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	COG3963 Phospholipid N-methyltransferase.	0.667
EAR23206.1	EAR20786.1	NB231_15338	NB231_10934	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase.	0.458
EAR23206.1	EAR23094.1	NB231_15338	NB231_14778	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Hypothetical acyltransferase family protein; COG1020 Non-ribosomal peptide synthetase modules and related proteins.	0.934
EAR23206.1	EAR23533.1	NB231_15338	NB231_16973	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Probable mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.527
EAR23206.1	psd	NB231_15338	NB231_00900	CDP-diacylglycerol--serine O-phosphatidyltransferase; COG1183 Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).	0.968

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Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.532

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

6 of 23

1.74

2.48

9.20e-07

GO:0019752

Carboxylic acid metabolic process

7 of 225

0.82

0.65

0.0018

GO:0071704

Organic substance metabolic process

11 of 1099

0.32

0.26

0.0194

GO:0044238

Primary metabolic process

10 of 910

0.36

0.26

0.0410

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

6 of 14

1.96

3.24

4.28e-08

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

4 of 10

1.93

2.07

4.75e-05

GO:0033818

Beta-ketoacyl-acyl-carrier-protein synthase III activity

3 of 4

2.2

1.84

0.00029

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

4 of 27

1.49

1.32

0.00072

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 776

0.47

0.4

0.00061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:767

Fatty acid biosynthesis

7 of 13

2.05

4.24

1.81e-10

CL:770

Beta-ketoacyl synthase, active site, and KR domain

4 of 6

2.15

2.71

3.26e-06

CL:643

Carbon metabolism, and Valine, leucine and isoleucine degradation

8 of 106

1.2

1.54

3.98e-07

CL:783

acetyl-CoA carboxylase complex, and Beta-ketoacyl-[acyl-carrier-protein] synthase III, N-terminal

2 of 5

1.93

0.87

0.0220

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

9 of 28

1.83

4.42

1.36e-13

map01212

Fatty acid metabolism

9 of 36

1.72

3.89

4.80e-13

map00780

Biotin metabolism

4 of 20

1.62

1.7

0.00010

map01100

Metabolic pathways

11 of 845

0.44

0.37

0.00044

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0444

Lipid biosynthesis

4 of 21

1.6

1.43

0.00059

KW-0275

Fatty acid biosynthesis

3 of 11

1.76

1.33

0.0017

KW-0511

Multifunctional enzyme

2 of 5

1.93

0.95

0.0153

KW-0012

Acyltransferase

3 of 32

1.3

0.78

0.0153

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08545

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III

3 of 4

2.2

1.58

0.0010

PF08541

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal

3 of 4

2.2

1.58

0.0010

PF08659

KR domain

3 of 8

1.9

1.4

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002347

Short-chain dehydrogenase/reductase SDR

4 of 10

1.93

1.76

0.00026

IPR013751

Beta-ketoacyl-[acyl-carrier-protein] synthase III, N-terminal

3 of 3

2.32

1.75

0.00051

IPR016039

Thiolase-like

4 of 13

1.81

1.67

0.00030

IPR013747

Beta-ketoacyl-[acyl-carrier-protein] synthase III, C-terminal

3 of 4

2.2

1.67

0.00066

IPR036291

NAD(P)-binding domain superfamily

5 of 62

1.23

1.03

0.0013

(more ...)

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