node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR20488.1 | EAR22531.1 | NB231_07040 | NB231_12364 | COG3151 Uncharacterized protein conserved in bacteria. | COG2716 Glycine cleavage system regulatory protein. | 0.608 |
EAR20488.1 | zipA | NB231_07040 | NB231_16143 | COG3151 Uncharacterized protein conserved in bacteria. | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.637 |
EAR21337.1 | EAR22531.1 | NB231_13121 | NB231_12364 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG2716 Glycine cleavage system regulatory protein. | 0.685 |
EAR21337.1 | gcvT | NB231_13121 | NB231_13216 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.941 |
EAR21337.1 | glyA | NB231_13121 | NB231_10088 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
EAR21942.1 | EAR22531.1 | NB231_06126 | NB231_12364 | Hypothetical protein. | COG2716 Glycine cleavage system regulatory protein. | 0.602 |
EAR22530.1 | EAR22531.1 | NB231_12359 | NB231_12364 | COG1225 Peroxiredoxin. | COG2716 Glycine cleavage system regulatory protein. | 0.652 |
EAR22530.1 | dapA | NB231_12359 | NB231_12369 | COG1225 Peroxiredoxin. | Dihydrodipicolinate synthase subfamily protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.511 |
EAR22531.1 | EAR20488.1 | NB231_12364 | NB231_07040 | COG2716 Glycine cleavage system regulatory protein. | COG3151 Uncharacterized protein conserved in bacteria. | 0.608 |
EAR22531.1 | EAR21337.1 | NB231_12364 | NB231_13121 | COG2716 Glycine cleavage system regulatory protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.685 |
EAR22531.1 | EAR21942.1 | NB231_12364 | NB231_06126 | COG2716 Glycine cleavage system regulatory protein. | Hypothetical protein. | 0.602 |
EAR22531.1 | EAR22530.1 | NB231_12364 | NB231_12359 | COG2716 Glycine cleavage system regulatory protein. | COG1225 Peroxiredoxin. | 0.652 |
EAR22531.1 | dapA | NB231_12364 | NB231_12369 | COG2716 Glycine cleavage system regulatory protein. | Dihydrodipicolinate synthase subfamily protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.767 |
EAR22531.1 | gcvPB | NB231_12364 | NB231_13236 | COG2716 Glycine cleavage system regulatory protein. | Glycine dehydrogenase subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.606 |
EAR22531.1 | gcvT | NB231_12364 | NB231_13216 | COG2716 Glycine cleavage system regulatory protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.699 |
EAR22531.1 | glyA | NB231_12364 | NB231_10088 | COG2716 Glycine cleavage system regulatory protein. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.710 |
EAR22531.1 | metG | NB231_12364 | NB231_09418 | COG2716 Glycine cleavage system regulatory protein. | Methionyl-tRNA synthetase, class Ia; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.730 |
EAR22531.1 | zipA | NB231_12364 | NB231_16143 | COG2716 Glycine cleavage system regulatory protein. | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.626 |
dapA | EAR22530.1 | NB231_12369 | NB231_12359 | Dihydrodipicolinate synthase subfamily protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | COG1225 Peroxiredoxin. | 0.511 |
dapA | EAR22531.1 | NB231_12369 | NB231_12364 | Dihydrodipicolinate synthase subfamily protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | COG2716 Glycine cleavage system regulatory protein. | 0.767 |