node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGH81622.1 | clpP | PCNPT3_08420 | PCNPT3_08685 | ClpV protein; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.922 |
AGH81622.1 | groL | PCNPT3_08420 | PCNPT3_09965 | ClpV protein; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin Cpn60, GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.542 |
AGH81622.1 | groS | PCNPT3_08420 | PCNPT3_09970 | ClpV protein; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.576 |
AGH81622.1 | grpE | PCNPT3_08420 | PCNPT3_08865 | ClpV protein; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.717 |
AGH81622.1 | lon | PCNPT3_08420 | PCNPT3_08675 | ClpV protein; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.601 |
AGH81787.1 | clpP | PCNPT3_09245 | PCNPT3_08685 | ATP-dependent Clp protease ATP-binding protein ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.920 |
AGH81787.1 | groL | PCNPT3_09245 | PCNPT3_09965 | ATP-dependent Clp protease ATP-binding protein ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Chaperonin Cpn60, GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.542 |
AGH81787.1 | groS | PCNPT3_09245 | PCNPT3_09970 | ATP-dependent Clp protease ATP-binding protein ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.576 |
AGH81787.1 | grpE | PCNPT3_09245 | PCNPT3_08865 | ATP-dependent Clp protease ATP-binding protein ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.717 |
AGH81787.1 | lon | PCNPT3_09245 | PCNPT3_08675 | ATP-dependent Clp protease ATP-binding protein ClpA; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.601 |
AGH82246.1 | clpP | PCNPT3_11550 | PCNPT3_08685 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.973 |
AGH82246.1 | clpX | PCNPT3_11550 | PCNPT3_08680 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | ATP-dependent protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.869 |
AGH82246.1 | groL | PCNPT3_11550 | PCNPT3_09965 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | Chaperonin Cpn60, GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.897 |
AGH82246.1 | groS | PCNPT3_11550 | PCNPT3_09970 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.750 |
AGH82246.1 | grpE | PCNPT3_11550 | PCNPT3_08865 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.929 |
AGH82246.1 | lon | PCNPT3_11550 | PCNPT3_08675 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.930 |
AGH82246.1 | tig | PCNPT3_11550 | PCNPT3_08690 | ATP-dependent M41 family peptidase; COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the AAA ATPase family. | Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.593 |
clpB | clpP | PCNPT3_02135 | PCNPT3_08685 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.925 |
clpB | groL | PCNPT3_02135 | PCNPT3_09965 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin Cpn60, GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.542 |
clpB | groS | PCNPT3_02135 | PCNPT3_09970 | Chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.576 |