EAR08626.1 protein (Reinekea blandensis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EAR08626.1

COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family. (398 aa)

Predicted Functional Partners:

EAR08628.1

0.868

EAR08627.1

0.851

EAR08619.1

0.760

EAR08621.1

0.746

EAR08639.1

0.740

EAR08622.1

0.720

EAR08620.1

0.710

EAR08638.1

0.702

EAR08623.1

0.697

EAR08637.1

0.670

Your Current Organism:

Reinekea blandensis

NCBI taxonomy Id: 314283
Other names: R. blandensis MED297, Reinekea blandensis MED297, Reinekea blandensis str. MED297, Reinekea blandensis strain MED297, Reinekea sp. MED297

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR08619.1	EAR08620.1	MED297_02905	MED297_02910	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	0.955
EAR08619.1	EAR08621.1	MED297_02905	MED297_02915	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	0.938
EAR08619.1	EAR08622.1	MED297_02905	MED297_02920	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	Hypothetical protein; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases.	0.945
EAR08619.1	EAR08623.1	MED297_02905	MED297_02925	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	COG0673 Predicted dehydrogenases and related proteins.	0.914
EAR08619.1	EAR08626.1	MED297_02905	MED297_02940	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.760
EAR08619.1	EAR08627.1	MED297_02905	MED297_02945	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	Possible protocatechuate 4,5-dioxygenase small subunit (AB035121).	0.781
EAR08619.1	EAR08628.1	MED297_02905	MED297_02950	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	Protocatechuate 4,5-dioxygenase beta chain.	0.786
EAR08619.1	EAR08638.1	MED297_02905	MED297_03000	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	Protocatechuate 4,5-dioxygenase, alpha chain.	0.781
EAR08619.1	EAR08639.1	MED297_02905	MED297_03005	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	Protocatechuate 4,5-dioxygenase, beta chain.	0.793
EAR08620.1	EAR08619.1	MED297_02910	MED297_02905	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	0.955
EAR08620.1	EAR08621.1	MED297_02910	MED297_02915	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	0.978
EAR08620.1	EAR08622.1	MED297_02910	MED297_02920	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	Hypothetical protein; COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases.	0.924
EAR08620.1	EAR08623.1	MED297_02910	MED297_02925	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	COG0673 Predicted dehydrogenases and related proteins.	0.771
EAR08620.1	EAR08626.1	MED297_02910	MED297_02940	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	COG0583 Transcriptional regulator; Belongs to the LysR transcriptional regulatory family.	0.710
EAR08620.1	EAR08627.1	MED297_02910	MED297_02945	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	Possible protocatechuate 4,5-dioxygenase small subunit (AB035121).	0.867
EAR08620.1	EAR08628.1	MED297_02910	MED297_02950	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	Protocatechuate 4,5-dioxygenase beta chain.	0.887
EAR08620.1	EAR08638.1	MED297_02910	MED297_03000	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	Protocatechuate 4,5-dioxygenase, alpha chain.	0.882
EAR08620.1	EAR08639.1	MED297_02910	MED297_03005	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	Protocatechuate 4,5-dioxygenase, beta chain.	0.899
EAR08621.1	EAR08619.1	MED297_02915	MED297_02905	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	Hypothetical protein; COG0684 Demethylmenaquinone methyltransferase.	0.938
EAR08621.1	EAR08620.1	MED297_02915	MED297_02910	2-pyrone-4,6-dicarboxylic acid hydrolase; COG3618 Predicted metal-dependent hydrolase of the TIM-barrel fold.	FldA protein; COG2828 Uncharacterized protein conserved in bacteria.	0.978

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Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.872

expected number of edges:

11

PPI enrichment p-value:

0.000614

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006259

DNA metabolic process

6 of 68

1.38

1.47

7.76e-05

GO:0006260

DNA replication

3 of 20

1.61

1.04

0.0063

GO:0044260

Cellular macromolecule metabolic process

8 of 212

1.01

0.99

7.76e-05

GO:0090304

Nucleic acid metabolic process

7 of 173

1.04

0.97

0.00023

GO:0006281

DNA repair

3 of 30

1.43

0.84

0.0146

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

7 of 40

1.68

2.85

1.25e-08

GO:0140640

Catalytic activity, acting on a nucleic acid

9 of 117

1.32

1.99

8.56e-09

GO:0008094

ATP-dependent activity, acting on DNA

3 of 11

1.87

1.43

0.0013

GO:0016779

Nucleotidyltransferase activity

4 of 40

1.43

1.19

0.0013

GO:0003677

DNA binding

7 of 146

1.11

1.17

3.94e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:434

Mismatch repair, and DNA-templated DNA replication

7 of 16

2.07

4.35

1.20e-10

CL:437

DNA damage sensor activity, and DNA-directed DNA polymerase

3 of 5

2.21

1.9

0.00022

CL:113

Cellular macromolecule metabolic process, and ATP-dependent activity

8 of 196

1.04

1.14

7.24e-06

CL:1684

Mixed, incl. UDP-N-acetylglucosamine metabolic process, and Phosphoglucosamine mutase activity

2 of 6

1.96

0.8

0.0313

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03430

Mismatch repair

5 of 21

1.81

2.51

1.54e-06

map03030

DNA replication

3 of 19

1.63

1.19

0.0029

map03440

Homologous recombination

3 of 21

1.59

1.17

0.0029

map00520

Amino sugar and nucleotide sugar metabolism

3 of 32

1.41

0.97

0.0059

map03420

Nucleotide excision repair

2 of 10

1.73

0.9

0.0167

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0238

DNA-binding

4 of 67

1.21

0.74

0.0159

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