node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR07950.1 | EAR07951.1 | MED297_04849 | MED297_04854 | Hypothetical protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | 0.994 |
EAR07950.1 | dnaE2 | MED297_04849 | MED297_04859 | Hypothetical protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.973 |
EAR07950.1 | lexA | MED297_04849 | MED297_16754 | Hypothetical protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.663 |
EAR07950.1 | recA | MED297_04849 | MED297_13572 | Hypothetical protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.707 |
EAR07951.1 | EAR07950.1 | MED297_04854 | MED297_04849 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Hypothetical protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.994 |
EAR07951.1 | EAR09557.1 | MED297_04854 | MED297_12537 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | COG0417 DNA polymerase elongation subunit (family B). | 0.970 |
EAR07951.1 | EAR09677.1 | MED297_04854 | MED297_15999 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Superfamily II DNA/RNA helicase, SNF2 family protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair. Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.809 |
EAR07951.1 | EAR09829.1 | MED297_04854 | MED297_05754 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.973 |
EAR07951.1 | EAR11295.1 | MED297_04854 | MED297_20447 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Ada regulatory protein; COG2169 Adenosine deaminase. | 0.839 |
EAR07951.1 | EAR11422.1 | MED297_04854 | MED297_21082 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. | 0.917 |
EAR07951.1 | dnaE2 | MED297_04854 | MED297_04859 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.978 |
EAR07951.1 | lexA | MED297_04854 | MED297_16754 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.907 |
EAR07951.1 | mrdB | MED297_04854 | MED297_03350 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Cell cycle protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.795 |
EAR07951.1 | recA | MED297_04854 | MED297_13572 | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.913 |
EAR09557.1 | EAR07951.1 | MED297_12537 | MED297_04854 | COG0417 DNA polymerase elongation subunit (family B). | Hypothetical protein; COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair. | 0.970 |
EAR09557.1 | EAR09677.1 | MED297_12537 | MED297_15999 | COG0417 DNA polymerase elongation subunit (family B). | Superfamily II DNA/RNA helicase, SNF2 family protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair. Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.812 |
EAR09557.1 | EAR09829.1 | MED297_12537 | MED297_05754 | COG0417 DNA polymerase elongation subunit (family B). | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.997 |
EAR09557.1 | EAR11295.1 | MED297_12537 | MED297_20447 | COG0417 DNA polymerase elongation subunit (family B). | Ada regulatory protein; COG2169 Adenosine deaminase. | 0.634 |
EAR09557.1 | lexA | MED297_12537 | MED297_16754 | COG0417 DNA polymerase elongation subunit (family B). | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.560 |
EAR09557.1 | recA | MED297_12537 | MED297_13572 | COG0417 DNA polymerase elongation subunit (family B). | Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.926 |