EAR08295.1 protein (Reinekea blandensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

EAR08295.1

Hypothetical protein. (674 aa)

Predicted Functional Partners:

EAR11093.1

0.884

EAR10547.1

0.859

EAR08095.1

0.814

EAR11307.1

0.814

EAR11028.1

0.812

EAR08593.1

0.785

EAR07252.1

0.785

EAR10035.1

0.785

EAR10546.1

0.785

EAR10200.1

0.785

Your Current Organism:

Reinekea blandensis

NCBI taxonomy Id: 314283
Other names: R. blandensis MED297, Reinekea blandensis MED297, Reinekea blandensis str. MED297, Reinekea blandensis strain MED297, Reinekea sp. MED297

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR07252.1	EAR08295.1	MED297_05389	MED297_09151	Hypothetical protein.	Hypothetical protein.	0.785
EAR08095.1	EAR08295.1	MED297_00365	MED297_09151	Cytochrome c family protein.	Hypothetical protein.	0.814
EAR08295.1	EAR07252.1	MED297_09151	MED297_05389	Hypothetical protein.	Hypothetical protein.	0.785
EAR08295.1	EAR08095.1	MED297_09151	MED297_00365	Hypothetical protein.	Cytochrome c family protein.	0.814
EAR08295.1	EAR08593.1	MED297_09151	MED297_02775	Hypothetical protein.	Hypothetical protein.	0.785
EAR08295.1	EAR10035.1	MED297_09151	MED297_08101	Hypothetical protein.	Hypothetical protein; COG2931 RTX toxins and related Ca2+-binding proteins.	0.785
EAR08295.1	EAR10200.1	MED297_09151	MED297_13292	Hypothetical protein.	Transmembrane protein, putative; COG3291 FOG: PKD repeat.	0.785
EAR08295.1	EAR10546.1	MED297_09151	MED297_11040	Hypothetical protein.	Hypothetical protein.	0.785
EAR08295.1	EAR10547.1	MED297_09151	MED297_11045	Hypothetical protein.	COG3210 Large exoproteins involved in heme utilization or adhesion.	0.859
EAR08295.1	EAR11028.1	MED297_09151	MED297_10971	Hypothetical protein.	COG2931 RTX toxins and related Ca2+-binding proteins.	0.812
EAR08295.1	EAR11093.1	MED297_09151	MED297_19437	Hypothetical protein.	Protein containing QXW lectin repeats.	0.884
EAR08295.1	EAR11307.1	MED297_09151	MED297_20507	Hypothetical protein.	Hypothetical protein.	0.814
EAR08593.1	EAR08295.1	MED297_02775	MED297_09151	Hypothetical protein.	Hypothetical protein.	0.785
EAR10035.1	EAR08295.1	MED297_08101	MED297_09151	Hypothetical protein; COG2931 RTX toxins and related Ca2+-binding proteins.	Hypothetical protein.	0.785
EAR10200.1	EAR08295.1	MED297_13292	MED297_09151	Transmembrane protein, putative; COG3291 FOG: PKD repeat.	Hypothetical protein.	0.785
EAR10200.1	EAR11028.1	MED297_13292	MED297_10971	Transmembrane protein, putative; COG3291 FOG: PKD repeat.	COG2931 RTX toxins and related Ca2+-binding proteins.	0.433
EAR10546.1	EAR08295.1	MED297_11040	MED297_09151	Hypothetical protein.	Hypothetical protein.	0.785
EAR10547.1	EAR08295.1	MED297_11045	MED297_09151	COG3210 Large exoproteins involved in heme utilization or adhesion.	Hypothetical protein.	0.859
EAR11028.1	EAR08295.1	MED297_10971	MED297_09151	COG2931 RTX toxins and related Ca2+-binding proteins.	Hypothetical protein.	0.812
EAR11028.1	EAR10200.1	MED297_10971	MED297_13292	COG2931 RTX toxins and related Ca2+-binding proteins.	Transmembrane protein, putative; COG3291 FOG: PKD repeat.	0.433

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.952

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006189

De novo IMP biosynthetic process

11 of 15

2.33

8.92

7.99e-22

GO:0009113

Purine nucleobase biosynthetic process

2 of 3

2.29

1.42

0.0022

GO:0006541

Glutamine metabolic process

2 of 16

1.57

0.75

0.0292

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034023

5-(carboxyamino)imidazole ribonucleotide mutase activity

3 of 3

2.47

1.86

0.00034

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

4 of 39

1.48

1.13

0.0025

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 215

0.84

0.45

0.0478

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:552

De novo IMP biosynthetic process

9 of 11

2.38

7.64

1.52e-17

CL:549

Purine nucleoside monophosphate biosynthetic process

11 of 24

2.13

7.4

2.88e-20

CL:555

De novo IMP biosynthetic process

5 of 5

2.47

4.26

4.66e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

11 of 95

1.53

3.38

2.94e-15

map01110

Biosynthesis of secondary metabolites

11 of 378

0.93

1.11

3.54e-09

map01100

Metabolic pathways

11 of 1142

0.45

0.39

0.00040

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

9 of 334

0.9

0.89

1.98e-05

GOCC:0005737

Cytoplasm

11 of 738

0.64

0.58

1.98e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

9 of 16

2.22

6.69

1.93e-16

KW-0436

Ligase

4 of 63

1.27

0.92

0.0047

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01001

AIR carboxylase

3 of 3

2.47

2.25

5.90e-05

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