node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR08075.1 | EAR09594.1 | MED297_07526 | MED297_12722 | Zinc protease; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | HflK; HflC and HflK could encode or regulate a protease. | 0.610 |
EAR08075.1 | EAR09595.1 | MED297_07526 | MED297_12727 | Zinc protease; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | HflC protein; HflC and HflK could regulate a protease. | 0.610 |
EAR08075.1 | ftsH | MED297_07526 | MED297_10701 | Zinc protease; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.753 |
EAR09594.1 | EAR08075.1 | MED297_12722 | MED297_07526 | HflK; HflC and HflK could encode or regulate a protease. | Zinc protease; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | 0.610 |
EAR09594.1 | EAR09595.1 | MED297_12722 | MED297_12727 | HflK; HflC and HflK could encode or regulate a protease. | HflC protein; HflC and HflK could regulate a protease. | 0.999 |
EAR09594.1 | ftsH | MED297_12722 | MED297_10701 | HflK; HflC and HflK could encode or regulate a protease. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.986 |
EAR09594.1 | hflX | MED297_12722 | MED297_12717 | HflK; HflC and HflK could encode or regulate a protease. | GTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.949 |
EAR09594.1 | hfq | MED297_12722 | MED297_12712 | HflK; HflC and HflK could encode or regulate a protease. | Uncharacterized host factor I protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.881 |
EAR09594.1 | hisZ | MED297_12722 | MED297_12732 | HflK; HflC and HflK could encode or regulate a protease. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.603 |
EAR09594.1 | miaA | MED297_12722 | MED297_12707 | HflK; HflC and HflK could encode or regulate a protease. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.857 |
EAR09594.1 | purA | MED297_12722 | MED297_12737 | HflK; HflC and HflK could encode or regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.618 |
EAR09595.1 | EAR08075.1 | MED297_12727 | MED297_07526 | HflC protein; HflC and HflK could regulate a protease. | Zinc protease; COG0612 Predicted Zn-dependent peptidases; Belongs to the peptidase M16 family. | 0.610 |
EAR09595.1 | EAR09594.1 | MED297_12727 | MED297_12722 | HflC protein; HflC and HflK could regulate a protease. | HflK; HflC and HflK could encode or regulate a protease. | 0.999 |
EAR09595.1 | bamB | MED297_12727 | MED297_15010 | HflC protein; HflC and HflK could regulate a protease. | Hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. | 0.731 |
EAR09595.1 | engB | MED297_12727 | MED297_05689 | HflC protein; HflC and HflK could regulate a protease. | Predicted GTPase; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.575 |
EAR09595.1 | ftsH | MED297_12727 | MED297_10701 | HflC protein; HflC and HflK could regulate a protease. | Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.982 |
EAR09595.1 | hflX | MED297_12727 | MED297_12717 | HflC protein; HflC and HflK could regulate a protease. | GTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.862 |
EAR09595.1 | hfq | MED297_12727 | MED297_12712 | HflC protein; HflC and HflK could regulate a protease. | Uncharacterized host factor I protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.889 |
EAR09595.1 | hisZ | MED297_12727 | MED297_12732 | HflC protein; HflC and HflK could regulate a protease. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.809 |
EAR09595.1 | miaA | MED297_12727 | MED297_12707 | HflC protein; HflC and HflK could regulate a protease. | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.835 |