node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAR08152.1 | EAR09659.1 | MED297_00650 | MED297_15909 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.943 |
EAR08152.1 | EAR10524.1 | MED297_00650 | MED297_01845 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | 0.987 |
EAR08152.1 | EAR10591.1 | MED297_00650 | MED297_11265 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | COG0631 Serine/threonine protein phosphatase. | 0.519 |
EAR08152.1 | clpP | MED297_00650 | MED297_05369 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.650 |
EAR08152.1 | clpP-2 | MED297_00650 | MED297_16529 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.650 |
EAR08152.1 | dnaJ | MED297_00650 | MED297_09691 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.990 |
EAR08152.1 | grpE | MED297_00650 | MED297_09681 | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.990 |
EAR09292.1 | EAR09659.1 | MED297_18428 | MED297_15909 | COG3517 Uncharacterized protein conserved in bacteria. | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.931 |
EAR09292.1 | EAR10591.1 | MED297_18428 | MED297_11265 | COG3517 Uncharacterized protein conserved in bacteria. | COG0631 Serine/threonine protein phosphatase. | 0.901 |
EAR09659.1 | EAR08152.1 | MED297_15909 | MED297_00650 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | 0.943 |
EAR09659.1 | EAR09292.1 | MED297_15909 | MED297_18428 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | COG3517 Uncharacterized protein conserved in bacteria. | 0.931 |
EAR09659.1 | EAR10524.1 | MED297_15909 | MED297_01845 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | 0.857 |
EAR09659.1 | EAR10591.1 | MED297_15909 | MED297_11265 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | COG0631 Serine/threonine protein phosphatase. | 0.916 |
EAR09659.1 | clpP | MED297_15909 | MED297_05369 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.933 |
EAR09659.1 | clpP-2 | MED297_15909 | MED297_16529 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.932 |
EAR09659.1 | clpS | MED297_15909 | MED297_15904 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Substrate modulator for ClpAP, directs protease activity towards aggregated proteins; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. | 0.995 |
EAR09659.1 | dnaJ | MED297_15909 | MED297_09691 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.866 |
EAR09659.1 | dnaK | MED297_15909 | MED297_09686 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
EAR09659.1 | grpE | MED297_15909 | MED297_09681 | COG0542 ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.854 |
EAR10524.1 | EAR08152.1 | MED297_01845 | MED297_00650 | Hypothetical protein; COG2214 DnaJ-class molecular chaperone. | Probable heat-shock protein Hsp 70; COG0443 Molecular chaperone. | 0.987 |