STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (723 aa)    
Predicted Functional Partners:
EAR09064.1
COG2224 Isocitrate lyase.
 
 
 0.989
EAR08225.1
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.955
EAR10507.1
Oxidoreductase, FAD-binding, putative; COG0277 FAD/FMN-containing dehydrogenases.
  
 
 0.921
EAR10135.1
Oxidoreductase, FAD-binding protein; COG0277 FAD/FMN-containing dehydrogenases.
  
 
 0.921
EAR09632.1
COG0372 Citrate synthase; Belongs to the citrate synthase family.
   
 0.914
prpB
PEP phosphonomutase and related enzyme; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
  
 
 0.906
EAR08914.1
COG0281 Malic enzyme.
    
 0.904
acsA
AMP-(fatty) acid ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 0.899
EAR08055.1
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
   
 0.898
EAR07616.1
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.892
Your Current Organism:
Reinekea blandensis
NCBI taxonomy Id: 314283
Other names: R. blandensis MED297, Reinekea blandensis MED297, Reinekea blandensis str. MED297, Reinekea blandensis strain MED297, Reinekea sp. MED297
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.