EAR09065.1 protein (Reinekea blandensis) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

EAR09065.1

Hypothetical protein. (250 aa)

Predicted Functional Partners:

EAR09066.1

0.904

EAR10624.1

0.743

EAR08595.1

0.688

EAR10186.1

0.672

EAR09338.1

0.619

EAR09388.1

0.590

EAR09030.1

0.582

EAR10918.1

0.582

EAR09470.1

0.574

EAR10616.1

0.551

Your Current Organism:

Reinekea blandensis

NCBI taxonomy Id: 314283
Other names: R. blandensis MED297, Reinekea blandensis MED297, Reinekea blandensis str. MED297, Reinekea blandensis strain MED297, Reinekea sp. MED297

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAR08595.1	EAR09065.1	MED297_02785	MED297_17023	Large extracellular alpha-helical protein; Protects the bacterial cell from host peptidases.	Hypothetical protein.	0.688
EAR09030.1	EAR09065.1	MED297_04037	MED297_17023	COG3487 Uncharacterized iron-regulated protein.	Hypothetical protein.	0.582
EAR09065.1	EAR08595.1	MED297_17023	MED297_02785	Hypothetical protein.	Large extracellular alpha-helical protein; Protects the bacterial cell from host peptidases.	0.688
EAR09065.1	EAR09030.1	MED297_17023	MED297_04037	Hypothetical protein.	COG3487 Uncharacterized iron-regulated protein.	0.582
EAR09065.1	EAR09066.1	MED297_17023	MED297_17028	Hypothetical protein.	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	0.904
EAR09065.1	EAR09338.1	MED297_17023	MED297_18658	Hypothetical protein.	Hypothetical protein.	0.619
EAR09065.1	EAR09388.1	MED297_17023	MED297_02172	Hypothetical protein.	ABC transporter, substrate-binding protein; COG1653 ABC-type sugar transport system, periplasmic component.	0.590
EAR09065.1	EAR09470.1	MED297_17023	MED297_02582	Hypothetical protein.	Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.574
EAR09065.1	EAR10186.1	MED297_17023	MED297_13222	Hypothetical protein.	Hypothetical protein.	0.672
EAR09065.1	EAR10616.1	MED297_17023	MED297_11390	Hypothetical protein.	Hypothetical protein; COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters.	0.551
EAR09065.1	EAR10624.1	MED297_17023	MED297_11430	Hypothetical protein.	COG1122 ABC-type cobalt transport system, ATPase component.	0.743
EAR09065.1	EAR10918.1	MED297_17023	MED297_10421	Hypothetical protein.	Hypothetical protein.	0.582
EAR09066.1	EAR09065.1	MED297_17028	MED297_17023	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	Hypothetical protein.	0.904
EAR09066.1	EAR09338.1	MED297_17028	MED297_18658	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	Hypothetical protein.	0.540
EAR09066.1	EAR09388.1	MED297_17028	MED297_02172	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	ABC transporter, substrate-binding protein; COG1653 ABC-type sugar transport system, periplasmic component.	0.573
EAR09066.1	EAR09470.1	MED297_17028	MED297_02582	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.583
EAR09066.1	EAR10186.1	MED297_17028	MED297_13222	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	Hypothetical protein.	0.434
EAR09338.1	EAR09065.1	MED297_18658	MED297_17023	Hypothetical protein.	Hypothetical protein.	0.619
EAR09338.1	EAR09066.1	MED297_18658	MED297_17028	Hypothetical protein.	Hypothetical protein; COG0477 Permeases of the major facilitator superfamily.	0.540
EAR09338.1	EAR09470.1	MED297_18658	MED297_02582	Hypothetical protein.	Hypothetical protein; COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).	0.450

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Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.89

expected number of edges:

16

PPI enrichment p-value:

8.11e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

10 of 72

1.73

4.07

6.34e-14

GO:0045333

Cellular respiration

4 of 44

1.54

1.37

0.00064

GO:0009060

Aerobic respiration

3 of 30

1.59

1.01

0.0074

GO:0006119

Oxidative phosphorylation

2 of 10

1.89

0.76

0.0356

GO:0044237

Cellular metabolic process

11 of 1633

0.41

0.33

0.0034

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

6 of 8

2.46

5.09

6.72e-11

GO:0009055

Electron transfer activity

9 of 55

1.8

4.13

9.54e-13

GO:0015078

Proton transmembrane transporter activity

6 of 25

1.97

3.51

8.09e-09

GO:0004129

Cytochrome-c oxidase activity

4 of 5

2.49

3.43

2.69e-07

GO:0022853

Active ion transmembrane transporter activity

6 of 39

1.77

2.86

7.06e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

4 of 6

2.41

3.17

7.50e-07

GO:0098803

Respiratory chain complex

2 of 3

2.41

1.27

0.0045

GO:0070069

Cytochrome complex

2 of 4

2.28

1.26

0.0045

GO:0016021

Integral component of membrane

8 of 957

0.51

0.34

0.0216

GO:0016020

Membrane

9 of 1329

0.42

0.3

0.0216

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3595

Mixed, incl. Oxidative phosphorylation, and Cytochrome c-like domain

8 of 53

1.76

3.52

1.64e-10

CL:3597

Mixed, incl. Oxidative phosphorylation, and NAD(P)-binding domain

6 of 28

1.92

3.41

8.48e-09

CL:3590

Mixed, incl. Oxidative phosphorylation, and Prosthetic group metabolic process

9 of 129

1.43

2.43

4.93e-10

CL:3604

Ubiquinol-cytochrome-c reductase activity, and Peptidase M16, zinc-binding site

3 of 5

2.36

2.2

6.57e-05

CL:3629

Cytochrome-c oxidase activity, and Respiratory chain complex IV assembly

3 of 6

2.28

2.11

8.95e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 47

1.82

3.96

9.83e-12

map01100

Metabolic pathways

11 of 1471

0.46

0.39

0.00060

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

7 of 24

2.05

4.41

5.39e-11

GOCC:0070069

Cytochrome complex

3 of 7

2.22

1.88

0.00024

GOCC:0098803

Respiratory chain complex

3 of 9

2.11

1.81

0.00029

GOCC:0045278

Plasma membrane respiratory chain complex IV

2 of 2

2.59

1.44

0.0023

GOCC:0016020

Membrane

9 of 848

0.61

0.48

0.0015

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

6 of 24

1.98

3.65

3.99e-09

KW-0679

Respiratory chain

4 of 5

2.49

3.51

1.85e-07

KW-0349

Heme

6 of 39

1.77

2.94

3.60e-08

KW-0408

Iron

8 of 92

1.53

2.6

2.69e-09

KW-0186

Copper

2 of 3

2.41

1.45

0.0021

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00115

Cytochrome C and Quinol oxidase polypeptide I

2 of 2

2.59

0.9

0.0235

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036909

Cytochrome c-like domain superfamily

4 of 22

1.85

1.57

0.00058

IPR036927

Cytochrome c oxidase-like, subunit I superfamily

2 of 2

2.59

0.93

0.0200

IPR023616

Cytochrome c oxidase-like, subunit I domain

2 of 2

2.59

0.93

0.0200

IPR023615

Cytochrome c oxidase, subunit I, copper-binding site

2 of 2

2.59

0.93

0.0200

IPR000883

Cytochrome c oxidase subunit I

2 of 2

2.59

0.93

0.0200

(more ...)

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