Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (909 aa)    
Predicted Functional Partners:
EAQ97597.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.995
EAQ96608.1
Domain protein of unknown function/Calcineurin-like phosphoesterase; DUF4174.
   
 0.973
EAQ96812.1
ATP-dependent DNA helicase RecQ.
  
 0.966
mutL
DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
  
 0.962
rnhA
Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 0.952
dinG
Rad3-related protein DNA helicase; DNA-dependent ATPase and 5'-3' DNA helicase.
   
 0.943
EAQ96890.2
Superfamily II DNA/RNA helicase, SNF2 family.
  
 0.937
EAQ96893.2
Hypothetical protein.
  
 0.937
EAQ97970.2
DNA polymerase III, gamma/tau subunit.
   
 0.934
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
 
 
 0.933
Your Current Organism:
Congregibacter litoralis
NCBI taxonomy Id: 314285
Other names: C. litoralis KT71, Congregibacter litoralis KT71, Congregibacter litoralis str. KT71, Congregibacter litoralis strain KT71, gamma proteobacterium KT71, unknown marine gamma proteobacterium NOR5
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.