STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAS46074.1hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (304 aa)    
Predicted Functional Partners:
EAS47257.1
enoyl-CoA hydratase/isomerase family protein; COG1024 Enoyl-CoA hydratase/carnithine racemase.
 
 
  0.972
EAS46191.1
Probable enoyl-CoA hydratase/isomerase; COG1024 Enoyl-CoA hydratase/carnithine racemase.
 
 
 
  0.968
EAS47203.1
Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
  
 0.927
EAS47258.1
hydroxymethylglutaryl-CoA lyase; COG0119 Isopropylmalate/homocitrate/citramalate synthases.
  
  
 
0.897
EAS46589.1
COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
  0.893
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
    
 0.891
EAS48156.1
COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
  0.891
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 
  0.879
EAS47641.1
COG0372 Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.877
EAS48125.1
COG2057 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit.
  
 
 0.860
Your Current Organism:
gamma proteobacterium HTCC2207
NCBI taxonomy Id: 314287
Other names: g. proteobacterium HTCC2207, marine gamma proteobacterium HTCC2207
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