EAS48117.1 protein (gamma proteobacterium HTCC2207)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EAS48117.1

Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases. (833 aa)

Predicted Functional Partners:

EAS48109.1

0.713

EAS46653.1

0.696

EAS46650.1

0.692

EAS48113.1

0.684

EAS46654.1

0.676

EAS46905.1

0.671

EAS48111.1

0.671

EAS48114.1

0.660

EAS46167.1

0.645

EAS48160.1

0.643

Your Current Organism:

gamma proteobacterium HTCC2207

NCBI taxonomy Id: 314287
Other names: g. proteobacterium HTCC2207, marine gamma proteobacterium HTCC2207

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAS46167.1	EAS48109.1	GB2207_00855	GB2207_09871	Laminarinase; COG3291 FOG: PKD repeat.	COG5520 O-Glycosyl hydrolase; Belongs to the glycosyl hydrolase 30 family.	0.705
EAS46167.1	EAS48117.1	GB2207_00855	GB2207_09911	Laminarinase; COG3291 FOG: PKD repeat.	Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases.	0.645
EAS46650.1	EAS46653.1	GB2207_03399	GB2207_03414	COG1629 Outer membrane receptor proteins, mostly Fe transport.	Pass1-related protein.	0.825
EAS46650.1	EAS46654.1	GB2207_03399	GB2207_03419	COG1629 Outer membrane receptor proteins, mostly Fe transport.	Putative tryptophan halogenase.	0.821
EAS46650.1	EAS48113.1	GB2207_03399	GB2207_09891	COG1629 Outer membrane receptor proteins, mostly Fe transport.	Pass1-related protein.	0.775
EAS46650.1	EAS48114.1	GB2207_03399	GB2207_09896	COG1629 Outer membrane receptor proteins, mostly Fe transport.	Tryptophan halogenase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.774
EAS46650.1	EAS48117.1	GB2207_03399	GB2207_09911	COG1629 Outer membrane receptor proteins, mostly Fe transport.	Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases.	0.692
EAS46653.1	EAS46650.1	GB2207_03414	GB2207_03399	Pass1-related protein.	COG1629 Outer membrane receptor proteins, mostly Fe transport.	0.825
EAS46653.1	EAS46654.1	GB2207_03414	GB2207_03419	Pass1-related protein.	Putative tryptophan halogenase.	0.929
EAS46653.1	EAS48111.1	GB2207_03414	GB2207_09881	Pass1-related protein.	TonB-dependent receptor, putative; COG1629 Outer membrane receptor proteins, mostly Fe transport.	0.783
EAS46653.1	EAS48114.1	GB2207_03414	GB2207_09896	Pass1-related protein.	Tryptophan halogenase, putative; COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.775
EAS46653.1	EAS48117.1	GB2207_03414	GB2207_09911	Pass1-related protein.	Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases.	0.696
EAS46654.1	EAS46650.1	GB2207_03419	GB2207_03399	Putative tryptophan halogenase.	COG1629 Outer membrane receptor proteins, mostly Fe transport.	0.821
EAS46654.1	EAS46653.1	GB2207_03419	GB2207_03414	Putative tryptophan halogenase.	Pass1-related protein.	0.929
EAS46654.1	EAS48111.1	GB2207_03419	GB2207_09881	Putative tryptophan halogenase.	TonB-dependent receptor, putative; COG1629 Outer membrane receptor proteins, mostly Fe transport.	0.775
EAS46654.1	EAS48113.1	GB2207_03419	GB2207_09891	Putative tryptophan halogenase.	Pass1-related protein.	0.775
EAS46654.1	EAS48117.1	GB2207_03419	GB2207_09911	Putative tryptophan halogenase.	Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases.	0.676
EAS46905.1	EAS48117.1	GB2207_04732	GB2207_09911	COG0860 N-acetylmuramoyl-L-alanine amidase.	Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases.	0.671
EAS48109.1	EAS46167.1	GB2207_09871	GB2207_00855	COG5520 O-Glycosyl hydrolase; Belongs to the glycosyl hydrolase 30 family.	Laminarinase; COG3291 FOG: PKD repeat.	0.705
EAS48109.1	EAS48117.1	GB2207_09871	GB2207_09911	COG5520 O-Glycosyl hydrolase; Belongs to the glycosyl hydrolase 30 family.	Glucan 1,4-beta-glucosidase; COG1472 Beta-glucosidase-related glycosidases.	0.713

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.847

expected number of edges:

18

PPI enrichment p-value:

0.000446

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006367

Transcription initiation from RNA polymerase II promoter

11 of 29

2.36

9.23

2.40e-22

GO:0051123

RNA polymerase II preinitiation complex assembly

9 of 15

2.56

8.65

9.70e-19

GO:0045893

Positive regulation of transcription, DNA-templated

5 of 122

1.4

1.47

9.32e-05

GO:0016573

Histone acetylation

3 of 29

1.8

1.43

0.0011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046982

Protein heterodimerization activity

6 of 24

2.18

4.03

2.86e-09

GO:0016251

RNA polymerase II general transcription initiation factor activity

3 of 10

2.26

1.78

0.00041

GO:0003713

Transcription coactivator activity

3 of 17

2.03

1.5

0.0012

GO:0017025

TBP-class protein binding

2 of 8

2.18

0.94

0.0180

GO:0005515

Protein binding

7 of 572

0.87

0.69

0.0019

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005669

Transcription factor TFIID complex

11 of 13

2.71

12.12

6.22e-26

GO:0046695

SLIK (SAGA-like) complex

4 of 5

2.69

4.08

2.05e-08

GO:0000124

SAGA complex

4 of 17

2.15

2.96

9.14e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2783

Transcription factor TFIID complex

10 of 12

2.7

10.66

1.64e-22

CL:2744

RNA Polymerase II Promoter Escape

11 of 32

2.32

9.06

1.64e-22

CL:2786

Transcription factor TFIID complex

5 of 5

2.78

5.21

1.47e-10

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03022

Basal transcription factors

11 of 48

2.14

7.81

1.32e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

11 of 42

2.2

8.08

2.29e-21

MAP-75953

RNA Polymerase II Transcription Initiation

11 of 42

2.2

8.08

2.29e-21

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

11 of 42

2.2

8.08

2.29e-21

MAP-73776

RNA Polymerase II Promoter Escape

11 of 42

2.2

8.08

2.29e-21

MAP-674695

RNA Polymerase II Pre-transcription Events

11 of 60

2.05

6.98

1.54e-20

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016591

RNA polymerase II, holoenzyme

9 of 40

2.14

6.12

1.34e-15

GOCC:0031981

Nuclear lumen

11 of 416

1.21

1.89

9.32e-12

GOCC:1902494

Catalytic complex

10 of 604

1.0

1.22

2.94e-08

GOCC:0032991

Protein-containing complex

11 of 1793

0.57

0.51

3.38e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009072

Histone-fold

5 of 22

2.14

2.99

7.19e-07

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Databases

Fusion

Textmining

Cooccurrence

Experiments

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About