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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdhAL-serine dehydratase, alpha subunit (L-serine deaminase); Belongs to the iron-sulfur dependent L-serine dehydratase family. (297 aa)    
Predicted Functional Partners:
sdhB
L-serine dehydratase, beta subunit (L-serine deaminase); Belongs to the iron-sulfur dependent L-serine dehydratase family.
 
 0.999
glyA
Glycine/Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.942
tdcB
Threonine deaminase (Threonine ammonia-lyase,Threonine dehydratase, IlvA homolog); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is acc [...]
  
 
 0.921
gloAN
Lactoylglutathione lyase (N-terminal fragment), authentic frameshift.
   
 
  0.800
LCA_0318
Putative oligopeptide transporter.
       0.742
LCA_0319
5 Proteins of unknown function that are similar to other proteins.
       0.741
pepD3
Dipeptidase D-type (U34 family).
     
 0.665
LCA_0321
Hypothetical integral membrane protein.
       0.614
LCA_0157
Putative hydroxyl/aromatic amino acid symporter.
 
  
 0.459
LCA_1057
Putative amino acid ABC transporter, substrate binding/permease subunit.
   
  
 0.443
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
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