dltA protein (Lactobacillus sakei) - STRING interaction network

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dltA

D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...] (510 aa)

Predicted Functional Partners:

dltB

0.999

dltC

0.999

dltD

0.995

ddl

0.953

alr

0.928

fabD

0.926

LCA_1042

0.920

LCA_0225

0.904

LCA_0538

0.904

LCA_1798

0.904

Your Current Organism:

Lactobacillus sakei

NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCA_0225	dltA	LCA_0225	LCA_0395	Putative oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	0.904
LCA_0538	dltA	LCA_0538	LCA_0395	Putative oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	0.904
LCA_1042	dltA	LCA_1042	LCA_0395	Putative oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	0.920
LCA_1798	dltA	LCA_1798	LCA_0395	Putative oxidoreductase, short chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	0.904
alr	ddl	LCA_1613	LCA_0049	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	D-alanine--D-alanine ligase (D-alanylalanine synthetase); Cell wall formation.	0.968
alr	dltA	LCA_1613	LCA_0395	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	0.928
alr	dltC	LCA_1613	LCA_0397	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	D-alanine-poly(phosphoribitol) ligase, subunit 2 (D-alanine-D-alanyl carrier protein); Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.	0.903
ddl	alr	LCA_0049	LCA_1613	D-alanine--D-alanine ligase (D-alanylalanine synthetase); Cell wall formation.	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	0.968
ddl	dltA	LCA_0049	LCA_0395	D-alanine--D-alanine ligase (D-alanylalanine synthetase); Cell wall formation.	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	0.953
ddl	dltC	LCA_0049	LCA_0397	D-alanine--D-alanine ligase (D-alanylalanine synthetase); Cell wall formation.	D-alanine-poly(phosphoribitol) ligase, subunit 2 (D-alanine-D-alanyl carrier protein); Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.	0.900
dltA	LCA_0225	LCA_0395	LCA_0225	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Putative oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.904
dltA	LCA_0538	LCA_0395	LCA_0538	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Putative oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.904
dltA	LCA_1042	LCA_0395	LCA_1042	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Putative oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.920
dltA	LCA_1798	LCA_0395	LCA_1798	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Putative oxidoreductase, short chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.904
dltA	alr	LCA_0395	LCA_1613	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	0.928
dltA	ddl	LCA_0395	LCA_0049	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	D-alanine--D-alanine ligase (D-alanylalanine synthetase); Cell wall formation.	0.953
dltA	dltB	LCA_0395	LCA_0396	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	D-alanyl transfer protein (membrane protein); Could be involved in the transport of activated D-alanine through the membrane.	0.999
dltA	dltC	LCA_0395	LCA_0397	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	D-alanine-poly(phosphoribitol) ligase, subunit 2 (D-alanine-D-alanyl carrier protein); Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.	0.999
dltA	dltD	LCA_0395	LCA_0398	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Lipoteichoic acid D-alanyl esterase precursor.	0.995
dltA	fabD	LCA_0395	LCA_0815	D-alanine-poly(phosphoribitol) ligase, subunit 1(D-alanine-D-alanyl carrier protein); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net [...]	Malonyl-CoA:ACP transacylase.	0.926

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