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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LCA_0406Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (410 aa)    
Predicted Functional Partners:
rnr
Exoribonuclease R, RNase II family; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
  
 0.995
LCA_0407
Putative phosphoesterase.
 
  
 0.993
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    0.989
LCA_0774
Putative ADP-ribose pyrophosphatase, NUDIX family.
  
 
 0.909
folE
GTP cyclohydrolase I.
  
  
 0.897
folK
2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase.
  
  
 0.897
guaA
Guanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP.
 
  
 0.864
LCA_0690
Putative rRNA methytransferase (sun protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
 
  
 0.861
rpsA
30S Ribosomal protein S1.
  
 0.858
rpsD
30S Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
  
  0.844
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
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