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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
manLMannose-specific phosphotransferase system, enzyme IIAB. (325 aa)    
Predicted Functional Partners:
manM
Mannose-specific phosphotransferase system, enzyme IIC.
 
 0.999
manN
Mannose-specific phosphotransferase system, enzyme IID.
 
 0.999
ptsH
Phosphocarrier protein HPr (Histidine-containing protein).
  
 0.999
LCA_0452
5 Proteins of unknown function that are similar to other proteins.
 
  
 0.979
manA
Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.
 
  
 0.972
scrK
Fructokinase.
    
 0.871
fruA
Fructose-specific phosphotransferase system, enzyme IIABC.
  
  
 0.843
ptsI
Phosphoenolpyruvate-protein phosphotransferase(Phosphotransferase system, enzyme I); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
  
  
 0.776
hprK
Hpr kinase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (gluc [...]
  
  
 0.749
nagA
N-acetylglucosamine-6-phosphate deacetylase.
  
  
 0.721
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
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