| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LCA_0345 | LCA_1240 | LCA_0345 | LCA_1240 | Putative Acyl-ACP thioesterase. | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.709 |
| LCA_0406 | LCA_1240 | LCA_0406 | LCA_1240 | Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.668 |
| LCA_0406 | LCA_1241 | LCA_0406 | LCA_1241 | Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Bifunctional enzyme, riboflavin kinase and FMN adenylyltransferase; Belongs to the ribF family. | 0.406 |
| LCA_0406 | infB | LCA_0406 | LCA_1248 | Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.464 |
| LCA_0406 | truB | LCA_0406 | LCA_1242 | Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | tRNA-specific pseudouridylate synthase (tRNA pseudouridine synthase B); Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.535 |
| LCA_1022 | LCA_1240 | LCA_1022 | LCA_1240 | Ferredoxin. | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.695 |
| LCA_1240 | LCA_0345 | LCA_1240 | LCA_0345 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Putative Acyl-ACP thioesterase. | 0.709 |
| LCA_1240 | LCA_0406 | LCA_1240 | LCA_0406 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.668 |
| LCA_1240 | LCA_1022 | LCA_1240 | LCA_1022 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Ferredoxin. | 0.695 |
| LCA_1240 | LCA_1241 | LCA_1240 | LCA_1241 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Bifunctional enzyme, riboflavin kinase and FMN adenylyltransferase; Belongs to the ribF family. | 0.824 |
| LCA_1240 | LCA_1243 | LCA_1240 | LCA_1243 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 6 Protein of unknown function, without similarity to other proteins. | 0.568 |
| LCA_1240 | LCA_1244 | LCA_1240 | LCA_1244 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 6 Protein of unknown function, without similarity to other proteins. | 0.542 |
| LCA_1240 | LCA_1661 | LCA_1240 | LCA_1661 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Putative nucleotide hydrolase, NUDIX family. | 0.569 |
| LCA_1240 | infB | LCA_1240 | LCA_1248 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. | 0.607 |
| LCA_1240 | lepA | LCA_1240 | LCA_1290 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | GTPase LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.833 |
| LCA_1240 | truB | LCA_1240 | LCA_1242 | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | tRNA-specific pseudouridylate synthase (tRNA pseudouridine synthase B); Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.807 |
| LCA_1241 | LCA_0406 | LCA_1241 | LCA_0406 | Bifunctional enzyme, riboflavin kinase and FMN adenylyltransferase; Belongs to the ribF family. | Putative nucleoside triphosphatase, Ham1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.406 |
| LCA_1241 | LCA_1240 | LCA_1241 | LCA_1240 | Bifunctional enzyme, riboflavin kinase and FMN adenylyltransferase; Belongs to the ribF family. | Putative coproporphyrinogen oxidase, HemN; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.824 |
| LCA_1241 | LCA_1243 | LCA_1241 | LCA_1243 | Bifunctional enzyme, riboflavin kinase and FMN adenylyltransferase; Belongs to the ribF family. | 6 Protein of unknown function, without similarity to other proteins. | 0.623 |
| LCA_1241 | LCA_1244 | LCA_1241 | LCA_1244 | Bifunctional enzyme, riboflavin kinase and FMN adenylyltransferase; Belongs to the ribF family. | 6 Protein of unknown function, without similarity to other proteins. | 0.542 |
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