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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LCA_1595Putative dihydrouridine synthetase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (328 aa)    
Predicted Functional Partners:
hslO
Molecular chaperone, Hsp33 family; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
  
  
 0.789
lysS
Lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.776
ftsH
ATP-dependent zinc metalloendopeptidase FtsH (cell division protein FtsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.748
tilS
Putative ATPase of the PP-loop superfamily, cell cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
  
  
 0.705
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
    0.683
prmA
Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
    
 0.589
LCA_0690
Putative rRNA methytransferase (sun protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
 
 
 0.566
hpt
Hypoxanthine phosphoribosyltranferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
    0.543
guaA
Guanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP.
  
  
 0.540
LCA_0165
Putative oxidoreductase, short chain dehydrogenase/reductase family.
  
 
 0.506
Your Current Organism:
Lactobacillus sakei
NCBI taxonomy Id: 314315
Other names: L. sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei 23K, Lactobacillus sakei subsp. sakei str. 23K, Lactobacillus sakei subsp. sakei strain 23K
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