| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| add | apt | LCA_0086 | LCA_1276 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.945 |
| add | guaA | LCA_0086 | LCA_0139 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | Guanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. | 0.798 |
| add | hpt | LCA_0086 | LCA_1598 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | Hypoxanthine phosphoribosyltranferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.927 |
| add | xpt | LCA_0086 | LCA_1557 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.480 |
| adk | apt | LCA_1744 | LCA_1276 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.922 |
| adk | guaA | LCA_1744 | LCA_0139 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. | 0.648 |
| adk | hpt | LCA_1744 | LCA_1598 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Hypoxanthine phosphoribosyltranferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.935 |
| adk | purA | LCA_1744 | LCA_0063 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Adenylosuccinate synthetase (IMP-aspartate ligase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.435 |
| adk | purH | LCA_1744 | LCA_0662 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Bifunctional protein:phospho ribosylaminoimidazole carboxamide formyltransferase (AICAR transformylase)and IMP cyclohydrolase (inosinicase). | 0.400 |
| apt | add | LCA_1276 | LCA_0086 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. | 0.945 |
| apt | adk | LCA_1276 | LCA_1744 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.922 |
| apt | guaA | LCA_1276 | LCA_0139 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. | 0.989 |
| apt | guaB | LCA_1276 | LCA_0276 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.652 |
| apt | hpt | LCA_1276 | LCA_1598 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltranferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.942 |
| apt | purA | LCA_1276 | LCA_0063 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase (IMP-aspartate ligase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.806 |
| apt | purH | LCA_1276 | LCA_0662 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional protein:phospho ribosylaminoimidazole carboxamide formyltransferase (AICAR transformylase)and IMP cyclohydrolase (inosinicase). | 0.978 |
| apt | xpt | LCA_1276 | LCA_1557 | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.949 |
| ftsH | guaA | LCA_1597 | LCA_0139 | ATP-dependent zinc metalloendopeptidase FtsH (cell division protein FtsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Guanosine monophosphate synthase (Glutamine amidotransferase); Catalyzes the synthesis of GMP from XMP. | 0.473 |
| ftsH | hpt | LCA_1597 | LCA_1598 | ATP-dependent zinc metalloendopeptidase FtsH (cell division protein FtsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Hypoxanthine phosphoribosyltranferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.926 |
| ftsH | tilS | LCA_1597 | LCA_1599 | ATP-dependent zinc metalloendopeptidase FtsH (cell division protein FtsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Putative ATPase of the PP-loop superfamily, cell cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. | 0.801 |
STRING v12.5 is now available!
